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Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist.
Willard FS, Douros JD, Gabe MB, Showalter AD, Wainscott DB, Suter TM, Capozzi ME, van der Velden WJ, Stutsman C, Cardona GR, Urva S, Emmerson PJ, Holst JJ, D'Alessio DA, Coghlan MP, Rosenkilde MM, Campbell JE, Sloop KW. Willard FS, et al. JCI Insight. 2020 Sep 3;5(17):e140532. doi: 10.1172/jci.insight.140532. JCI Insight. 2020. PMID: 32730231 Free PMC article.
Ildr1 gene deletion protects against diet-induced obesity and hyperglycemia.
Chandra R, Aryal DK, Douros JD, Shahid R, Davis SJ, Campbell JE, Ilkayeya O, White PJ, Rodriguez R, Newgard CB, Wetsel WC, Liddle RA. Chandra R, et al. PLoS One. 2022 Jun 24;17(6):e0270329. doi: 10.1371/journal.pone.0270329. eCollection 2022. PLoS One. 2022. PMID: 35749484 Free PMC article.
Control of leptin by metabolic state and its regulatory interactions with pituitary growth hormone and hepatic growth hormone receptors and insulin like growth factors in the tilapia (Oreochromis mossambicus).
Douros JD, Baltzegar DA, Mankiewicz J, Taylor J, Yamaguchi Y, Lerner DT, Seale AP, Grau EG, Breves JP, Borski RJ. Douros JD, et al. Gen Comp Endocrinol. 2017 Jan 1;240:227-237. doi: 10.1016/j.ygcen.2016.07.017. Epub 2016 Jul 19. Gen Comp Endocrinol. 2017. PMID: 27449341 Free PMC article.
Sleeve gastrectomy rapidly enhances islet function independently of body weight.
Douros JD, Niu J, Sdao S, Gregg T, Fisher-Wellman K, Bharadwaj M, Molina A, Arumugam R, Martin M, Petretto E, Merrins MJ, Herman MA, Tong J, Campbell J, D'Alessio D. Douros JD, et al. JCI Insight. 2019 Mar 21;4(6):e126688. doi: 10.1172/jci.insight.126688. eCollection 2019 Mar 21. JCI Insight. 2019. PMID: 30777938 Free PMC article.
Reg3 Proteins as Gut Hormones? Don't Be Hasty.
Douros JD, Campbell JE. Douros JD, et al. Endocrinology. 2019 Jul 1;160(7):1677-1678. doi: 10.1210/en.2019-00356. Endocrinology. 2019. PMID: 31099826 Free PMC article. No abstract available.