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ORF3c is expressed in SARS-CoV-2-infected cells and inhibits innate sensing by targeting MAVS.
Müller M, Herrmann A, Fujita S, Uriu K, Kruth C, Strange A, Kolberg JE, Schneider M, Ito J, Müller MA, Drosten C, Ensser A; Genotype to Phenotype Japan (G2P-Japan) Consortium; Sato K, Sauter D. Müller M, et al. EMBO Rep. 2023 Dec 6;24(12):e57137. doi: 10.15252/embr.202357137. Epub 2023 Oct 23. EMBO Rep. 2023. PMID: 37870297 Free PMC article.
Genetic barrier to resistance: a critical parameter for efficacy of neutralizing monoclonal antibodies against SARS-CoV-2 in a nonhuman primate model.
Stahl-Hennig C, Peter AS, Cordsmeier A, Stolte-Leeb N, Vestweber R, Socher E, Merida SA, Sauermann U, Bleyer M, Fraedrich K, Grunwald T, Winkler TH, Ensser A, Jäck H-M, Überla K. Stahl-Hennig C, et al. J Virol. 2024 Jul 23;98(7):e0062824. doi: 10.1128/jvi.00628-24. Epub 2024 Jun 20. J Virol. 2024. PMID: 38899895 Free PMC article.