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Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival.
Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, Moses HL, Weaver VM, Maitra A, Allison JP, LeBleu VS, Kalluri R. Özdemir BC, et al. Cancer Cell. 2014 Jun 16;25(6):719-34. doi: 10.1016/j.ccr.2014.04.005. Epub 2014 May 22. Cancer Cell. 2014. PMID: 24856586 Free PMC article.
Origin and function of myofibroblasts in kidney fibrosis.
LeBleu VS, Taduri G, O'Connell J, Teng Y, Cooke VG, Woda C, Sugimoto H, Kalluri R. LeBleu VS, et al. Nat Med. 2013 Aug;19(8):1047-53. doi: 10.1038/nm.3218. Epub 2013 Jun 30. Nat Med. 2013. PMID: 23817022 Free PMC article.