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SARS-CoV-2 variants, spike mutations and immune escape.
Harvey WT, Carabelli AM, Jackson B, Gupta RK, Thomson EC, Harrison EM, Ludden C, Reeve R, Rambaut A; COVID-19 Genomics UK (COG-UK) Consortium; Peacock SJ, Robertson DL. Harvey WT, et al. Nat Rev Microbiol. 2021 Jul;19(7):409-424. doi: 10.1038/s41579-021-00573-0. Epub 2021 Jun 1. Nat Rev Microbiol. 2021. PMID: 34075212 Free PMC article. Review.
Protocol for the COG-UK hospital-onset COVID-19 infection (HOCI) multicentre interventional clinical study: evaluating the efficacy of rapid genome sequencing of SARS-CoV-2 in limiting the spread of COVID-19 in UK NHS hospitals.
Blackstone J, Stirrup O, Mapp F, Panca M, Copas A, Flowers P, Hockey L, Price J, Partridge D, Peters C, de Silva T, Nebbia G, Snell LB, McComish R; COVID-19 Genomics UK (COG-UK) Consortium; Breuer J. Blackstone J, et al. BMJ Open. 2022 Apr 19;12(4):e052514. doi: 10.1136/bmjopen-2021-052514. BMJ Open. 2022. PMID: 35440446 Free PMC article.
Combining viral genomics and clinical data to assess risk factors for severe COVID-19 (mortality, ICU admission, or intubation) amongst hospital patients in a large acute UK NHS hospital Trust.
Foxley-Marrable M, D'Cruz L, Meredith P, Glaysher S, Beckett AH, Goudarzi S, Fearn C, Cook KF, Loveson KF, Dent H, Paul H, Elliott S, Wyllie S, Lloyd A, Bicknell K, Lumley S, McNicholas J, Prytherch D; COVID-19 Genomics UK (COG-UK) consortium; Lundgren A, Graur O, Chauhan AJ, Robson SC. Foxley-Marrable M, et al. PLoS One. 2023 Mar 23;18(3):e0283447. doi: 10.1371/journal.pone.0283447. eCollection 2023. PLoS One. 2023. PMID: 36952555 Free PMC article.
Prevalence of persistent SARS-CoV-2 in a large community surveillance study.
Ghafari M, Hall M, Golubchik T, Ayoubkhani D, House T, MacIntyre-Cockett G, Fryer HR, Thomson L, Nurtay A, Kemp SA, Ferretti L, Buck D, Green A, Trebes A, Piazza P, Lonie LJ, Studley R, Rourke E, Smith DL, Bashton M, Nelson A, Crown M, McCann C, Young GR, Santos RAND, Richards Z, Tariq MA, Cahuantzi R; Wellcome Sanger Institute COVID-19 Surveillance Team; COVID-19 Infection Survey Group; COVID-19 Genomics UK (COG-UK) Consortium; Barrett J, Fraser C, Bonsall D, Walker AS, Lythgoe K. Ghafari M, et al. Nature. 2024 Feb;626(8001):1094-1101. doi: 10.1038/s41586-024-07029-4. Epub 2024 Feb 21. Nature. 2024. PMID: 38383783 Free PMC article.
Comparative analysis of the risks of hospitalisation and death associated with SARS-CoV-2 omicron (B.1.1.529) and delta (B.1.617.2) variants in England: a cohort study.
Nyberg T, Ferguson NM, Nash SG, Webster HH, Flaxman S, Andrews N, Hinsley W, Bernal JL, Kall M, Bhatt S, Blomquist P, Zaidi A, Volz E, Aziz NA, Harman K, Funk S, Abbott S; COVID-19 Genomics UK (COG-UK) consortium; Hope R, Charlett A, Chand M, Ghani AC, Seaman SR, Dabrera G, De Angelis D, Presanis AM, Thelwall S. Nyberg T, et al. Lancet. 2022 Apr 2;399(10332):1303-1312. doi: 10.1016/S0140-6736(22)00462-7. Epub 2022 Mar 16. Lancet. 2022. PMID: 35305296 Free PMC article.
The role of viral genomics in understanding COVID-19 outbreaks in long-term care facilities.
Aggarwal D, Myers R, Hamilton WL, Bharucha T, Tumelty NM, Brown CS, Meader EJ, Connor T, Smith DL, Bradley DT, Robson S, Bashton M, Shallcross L, Zambon M, Goodfellow I, Chand M, O'Grady J, Török ME, Peacock SJ, Page AJ; COVID-19 Genomics UK (COG-UK) Consortium. Aggarwal D, et al. Lancet Microbe. 2022 Feb;3(2):e151-e158. doi: 10.1016/S2666-5247(21)00208-1. Epub 2021 Sep 29. Lancet Microbe. 2022. PMID: 34608459 Free PMC article. Review.
CLIMB-COVID: continuous integration supporting decentralised sequencing for SARS-CoV-2 genomic surveillance.
Nicholls SM, Poplawski R, Bull MJ, Underwood A, Chapman M, Abu-Dahab K, Taylor B, Colquhoun RM, Rowe WPM, Jackson B, Hill V, O'Toole Á, Rey S, Southgate J, Amato R, Livett R, Gonçalves S, Harrison EM, Peacock SJ, Aanensen DM, Rambaut A, Connor TR, Loman NJ; COVID-19 Genomics UK (COG-UK) Consortium. Nicholls SM, et al. Genome Biol. 2021 Jul 1;22(1):196. doi: 10.1186/s13059-021-02395-y. Genome Biol. 2021. PMID: 34210356 Free PMC article.
Tracking SARS-CoV-2 mutations and variants through the COG-UK-Mutation Explorer.
Wright DW, Harvey WT, Hughes J, Cox M, Peacock TP, Colquhoun R, Jackson B, Orton R, Nielsen M, Hsu NS; COVID-19 Genomics UK (COG-UK) consortium; Harrison EM, de Silva TI, Rambaut A, Peacock SJ, Robertson DL, Carabelli AM. Wright DW, et al. Virus Evol. 2022 Mar 18;8(1):veac023. doi: 10.1093/ve/veac023. eCollection 2022. Virus Evol. 2022. PMID: 35502202 Free PMC article.
Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope.
Dolton G, Rius C, Hasan MS, Wall A, Szomolay B, Behiry E, Whalley T, Southgate J, Fuller A; COVID-19 Genomics UK (COG-UK) consortium; Morin T, Topley K, Tan LR, Goulder PJR, Spiller OB, Rizkallah PJ, Jones LC, Connor TR, Sewell AK. Dolton G, et al. Cell. 2022 Aug 4;185(16):2936-2951.e19. doi: 10.1016/j.cell.2022.07.002. Epub 2022 Jul 14. Cell. 2022. PMID: 35931021 Free PMC article.
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway.
Willett BJ, Grove J, MacLean OA, Wilkie C, De Lorenzo G, Furnon W, Cantoni D, Scott S, Logan N, Ashraf S, Manali M, Szemiel A, Cowton V, Vink E, Harvey WT, Davis C, Asamaphan P, Smollett K, Tong L, Orton R, Hughes J, Holland P, Silva V, Pascall DJ, Puxty K, da Silva Filipe A, Yebra G, Shaaban S, Holden MTG, Pinto RM, Gunson R, Templeton K, Murcia PR, Patel AH, Klenerman P, Dunachie S; PITCH Consortium; COVID-19 Genomics UK (COG-UK) Consortium; Haughney J, Robertson DL, Palmarini M, Ray S, Thomson EC. Willett BJ, et al. Nat Microbiol. 2022 Aug;7(8):1161-1179. doi: 10.1038/s41564-022-01143-7. Epub 2022 Jul 7. Nat Microbiol. 2022. PMID: 35798890 Free PMC article.
84 results