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Emerging roles of DYRK2 in cancer.
Tandon V, de la Vega L, Banerjee S. Tandon V, et al. J Biol Chem. 2021 Jan-Jun;296:100233. doi: 10.1074/jbc.REV120.015217. Epub 2021 Jan 7. J Biol Chem. 2021. PMID: 33376136 Free PMC article. Review.
Isomeric O-methyl cannabidiolquinones with dual BACH1/NRF2 activity.
Casares L, Unciti-Broceta JD, Prados ME, Caprioglio D, Mattoteia D, Higgins M, Apendino G, Dinkova-Kostova AT, Muñoz E, de la Vega L. Casares L, et al. Redox Biol. 2020 Oct;37:101689. doi: 10.1016/j.redox.2020.101689. Epub 2020 Aug 22. Redox Biol. 2020. PMID: 32863231 Free PMC article.
Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression.
Banerjee S, Wei T, Wang J, Lee JJ, Gutierrez HL, Chapman O, Wiley SE, Mayfield JE, Tandon V, Juarez EF, Chavez L, Liang R, Sah RL, Costello C, Mesirov JP, de la Vega L, Cooper KL, Dixon JE, Xiao J, Lei X. Banerjee S, et al. Proc Natl Acad Sci U S A. 2019 Dec 3;116(49):24881-24891. doi: 10.1073/pnas.1912033116. Epub 2019 Nov 21. Proc Natl Acad Sci U S A. 2019. PMID: 31754034 Free PMC article.
Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1.
Casares L, García V, Garrido-Rodríguez M, Millán E, Collado JA, García-Martín A, Peñarando J, Calzado MA, de la Vega L, Muñoz E. Casares L, et al. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5. Redox Biol. 2020. PMID: 31518892 Free PMC article.
Dual inhibition of HSF1 and DYRK2 impedes cancer progression.
Tandon V, Moreno R, Allmeroth K, Quinn J, Wiley SE, Nicely LG, Denzel MS, Edwards J, de la Vega L, Banerjee S. Tandon V, et al. Biosci Rep. 2023 Jan 31;43(1):BSR20222102. doi: 10.1042/BSR20222102. Biosci Rep. 2023. PMID: 36622366 Free PMC article.
The synthetic triterpenoids CDDO-TFEA and CDDO-Me, but not CDDO, promote nuclear exclusion of BACH1 impairing its activity.
Casares L, Moreno R, Ali KX, Higgins M, Dayalan Naidu S, Neill G, Cassin L, Kiib AE, Svenningsen EB, Minassi A, Honda T, Poulsen TB, Wiel C, Sayin VI, Dinkova-Kostova AT, Olagnier D, de la Vega L. Casares L, et al. Redox Biol. 2022 May;51:102291. doi: 10.1016/j.redox.2022.102291. Epub 2022 Mar 17. Redox Biol. 2022. PMID: 35313207 Free PMC article.