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A bioisostere of Dimebon/Latrepirdine delays the onset and slows the progression of pathology in FUS transgenic mice.
CNS Neurosci Ther. 2021 Jul;27(7):765-775. doi: 10.1111/cns.13637. Epub 2021 Mar 23.
CNS Neurosci Ther. 2021.
PMID: 33754495
Free PMC article.
Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis.
Shelkovnikova TA, Kukharsky MS, An H, Dimasi P, Alexeeva S, Shabir O, Heath PR, Buchman VL.
Shelkovnikova TA, et al.
Mol Neurodegener. 2018 Jun 1;13(1):30. doi: 10.1186/s13024-018-0263-7.
Mol Neurodegener. 2018.
PMID: 29859124
Free PMC article.
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ALS-linked FUS mutations confer loss and gain of function in the nucleus by promoting excessive formation of dysfunctional paraspeckles.
An H, Skelt L, Notaro A, Highley JR, Fox AH, La Bella V, Buchman VL, Shelkovnikova TA.
An H, et al.
Acta Neuropathol Commun. 2019 Jan 14;7(1):7. doi: 10.1186/s40478-019-0658-x.
Acta Neuropathol Commun. 2019.
PMID: 30642400
Free PMC article.
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