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Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity.
Raj P, Rai E, Song R, Khan S, Wakeland BE, Viswanathan K, Arana C, Liang C, Zhang B, Dozmorov I, Carr-Johnson F, Mitrovic M, Wiley GB, Kelly JA, Lauwerys BR, Olsen NJ, Cotsapas C, Garcia CK, Wise CA, Harley JB, Nath SK, James JA, Jacob CO, Tsao BP, Pasare C, Karp DR, Li QZ, Gaffney PM, Wakeland EK. Raj P, et al. Elife. 2016 Feb 15;5:e12089. doi: 10.7554/eLife.12089. Elife. 2016. PMID: 26880555 Free PMC article.
Systemic IFN-alpha drives kidney nephritis in B6.Sle123 mice.
Fairhurst AM, Mathian A, Connolly JE, Wang A, Gray HF, George TA, Boudreaux CD, Zhou XJ, Li QZ, Koutouzov S, Banchereau J, Wakeland EK. Fairhurst AM, et al. Eur J Immunol. 2008 Jul;38(7):1948-60. doi: 10.1002/eji.200837925. Eur J Immunol. 2008. PMID: 18506882 Free PMC article.