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Page 1
The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease.
Hur JY, Frost GR, Wu X, Crump C, Pan SJ, Wong E, Barros M, Li T, Nie P, Zhai Y, Wang JC, Tcw J, Guo L, McKenzie A, Ming C, Zhou X, Wang M, Sagi Y, Renton AE, Esposito BT, Kim Y, Sadleir KR, Trinh I, Rissman RA, Vassar R, Zhang B, Johnson DS, Masliah E, Greengard P, Goate A, Li YM. Hur JY, et al. Nature. 2020 Oct;586(7831):735-740. doi: 10.1038/s41586-020-2681-2. Epub 2020 Sep 2. Nature. 2020. PMID: 32879487 Free PMC article.
Versatility of presenilin 1.
Frost GR, Wong E, Li YM. Frost GR, et al. Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):6885-6887. doi: 10.1073/pnas.1707809114. Epub 2017 Jun 23. Proc Natl Acad Sci U S A. 2017. PMID: 28645897 Free PMC article. No abstract available.
A miniaturized 1536-well format gamma-secretase assay.
Shelton CC, Tian Y, Shum D, Radu C, Djaballah H, Li YM. Shelton CC, et al. Assay Drug Dev Technol. 2009 Oct;7(5):461-70. doi: 10.1089/adt.2009.0202. Assay Drug Dev Technol. 2009. PMID: 19715456 Free PMC article.
Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.
Kounnas MZ, Danks AM, Cheng S, Tyree C, Ackerman E, Zhang X, Ahn K, Nguyen P, Comer D, Mao L, Yu C, Pleynet D, Digregorio PJ, Velicelebi G, Stauderman KA, Comer WT, Mobley WC, Li YM, Sisodia SS, Tanzi RE, Wagner SL. Kounnas MZ, et al. Neuron. 2010 Sep 9;67(5):769-80. doi: 10.1016/j.neuron.2010.08.018. Neuron. 2010. PMID: 20826309 Free PMC article.
40 results