Abstract
Drug hypersensitivity reactions are an important cause of morbidity in HIV-infected patients who take complex medication regimens. Correct diagnosis and management of these reactions are essential in the clinical care of HIV disease. Trimethoprim-sulfamethoxazole, abacavir, nevirapine, atazanavir, and enfuvirtide can all cause hypersensitivity rashes. In this review, we discuss the evidence for immunologic mechanisms of hypersensitivity reactions to HIV medications, the clinical characteristics of these reactions, and guidelines that currently exist for their identification and management.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Anti-Bacterial Agents / adverse effects
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Anti-Bacterial Agents / metabolism
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Anti-HIV Agents / adverse effects*
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Anti-HIV Agents / metabolism
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Drug Hypersensitivity / diagnosis*
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Drug Hypersensitivity / immunology
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Drug Hypersensitivity / therapy*
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Drug Hypersensitivity / virology
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Exanthema / diagnosis*
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Exanthema / immunology
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Exanthema / therapy*
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Exanthema / virology
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HIV Infections / complications
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HIV Infections / drug therapy
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HIV Infections / immunology*
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HIV Infections / therapy*
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Humans
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Immunosuppressive Agents / adverse effects*
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Immunosuppressive Agents / metabolism
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Practice Guidelines as Topic
Substances
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Anti-Bacterial Agents
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Anti-HIV Agents
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Immunosuppressive Agents