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Page 1
Histology-specific microRNA alterations in melanoma.
Poliseno L, Haimovic A, Segura MF, Hanniford D, Christos PJ, Darvishian F, Wang J, Shapiro RL, Pavlick AC, Berman RS, Hernando E, Zavadil J, Osman I. Poliseno L, et al. J Invest Dermatol. 2012 Jul;132(7):1860-8. doi: 10.1038/jid.2011.451. Epub 2012 May 3. J Invest Dermatol. 2012. PMID: 22551973 Free PMC article.
Reversal of NK-cell exhaustion in advanced melanoma by Tim-3 blockade.
da Silva IP, Gallois A, Jimenez-Baranda S, Khan S, Anderson AC, Kuchroo VK, Osman I, Bhardwaj N. da Silva IP, et al. Cancer Immunol Res. 2014 May;2(5):410-22. doi: 10.1158/2326-6066.CIR-13-0171. Epub 2014 Feb 11. Cancer Immunol Res. 2014. PMID: 24795354 Free PMC article.
Phosphorylated 4E-BP1 is associated with poor survival in melanoma.
O'Reilly KE, Warycha M, Davies MA, Rodrik V, Zhou XK, Yee H, Polsky D, Pavlick AC, Rosen N, Bhardwaj N, Mills G, Osman I. O'Reilly KE, et al. Clin Cancer Res. 2009 Apr 15;15(8):2872-8. doi: 10.1158/1078-0432.CCR-08-2336. Epub 2009 Mar 31. Clin Cancer Res. 2009. PMID: 19336517 Free PMC article.
Meta-analysis of sentinel lymph node positivity in thin melanoma (<or=1 mm).
Warycha MA, Zakrzewski J, Ni Q, Shapiro RL, Berman RS, Pavlick AC, Polsky D, Mazumdar M, Osman I. Warycha MA, et al. Cancer. 2009 Feb 15;115(4):869-79. doi: 10.1002/cncr.24044. Cancer. 2009. PMID: 19117354 Free PMC article.
RESULTS: Thirty-four studies comprising 3651 patients met inclusion criteria. The pooled SLN positivity rate was 5.6%. Significant heterogeneity among studies was detected (P = .005). There was no statistical evidence of publication bias (P = .21). ...Among the tumors from …
RESULTS: Thirty-four studies comprising 3651 patients met inclusion criteria. The pooled SLN positivity rate was 5.6%. Significant he …
Clinical relevance of SKP2 alterations in metastatic melanoma.
Rose AE, Wang G, Hanniford D, Monni S, Tu T, Shapiro RL, Berman RS, Pavlick AC, Pagano M, Darvishian F, Mazumdar M, Hernando E, Osman I. Rose AE, et al. Pigment Cell Melanoma Res. 2011 Feb;24(1):197-206. doi: 10.1111/j.1755-148X.2010.00784.x. Epub 2010 Oct 21. Pigment Cell Melanoma Res. 2011. PMID: 20883453 Free PMC article.
Impact of age on the management of primary melanoma patients.
Fleming NH, Tian J, Vega-Saenz de Miera E, Gold H, Darvishian F, Pavlick AC, Berman RS, Shapiro RL, Polsky D, Osman I. Fleming NH, et al. Oncology. 2013;85(3):173-81. doi: 10.1159/000351499. Epub 2013 Aug 30. Oncology. 2013. PMID: 24008821 Free PMC article.
RESULTS: 444 primary melanoma patients were categorized into three groups by age at diagnosis: 19-45 years (24.3%), 46-70 (50.2%), and 71-95 (25.5%). In multivariate models, older patients experienced a higher risk of recurrence (hazard ratio 3.34, 95% confidence interval, …
RESULTS: 444 primary melanoma patients were categorized into three groups by age at diagnosis: 19-45 years (24.3%), 46-70 (50.2%), and 71-95 …
Changes in the presentation of nodular and superficial spreading melanomas over 35 years.
Warycha MA, Christos PJ, Mazumdar M, Darvishian F, Shapiro RL, Berman RS, Pavlick AC, Kopf AW, Polsky D, Osman I. Warycha MA, et al. Cancer. 2008 Dec 15;113(12):3341-8. doi: 10.1002/cncr.23955. Cancer. 2008. PMID: 18988292 Free PMC article.
The median duration of NMs was reported to be only 5 months compared with 9 months in SSM patients. CONCLUSIONS: The authors' data suggest that improvements have been made in the early detection of SSM but not NM. ...
The median duration of NMs was reported to be only 5 months compared with 9 months in SSM patients. CONCLUSIONS: The authors' data su …
A high proliferative index of recurrent melanoma is associated with worse survival.
Tu TJ, Ma MW, Monni S, Rose AE, Yee H, Darvishian F, Polsky D, Berman RS, Shapiro RL, Pavlick AC, Mazumdar M, Osman I. Tu TJ, et al. Oncology. 2011;80(3-4):181-7. doi: 10.1159/000328518. Epub 2011 Jun 24. Oncology. 2011. PMID: 21701232 Free PMC article.
On univariate analysis, the median overall survival of patients whose recurrent tumors overexpressed Ki-67 was significantly shorter than that of patients whose recurrent tumors had low Ki-67 expression (3.6 vs. 9.5 years, p = 0.03). On multivariate analysis, a high prolif …
On univariate analysis, the median overall survival of patients whose recurrent tumors overexpressed Ki-67 was significantly shorter than th …