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Hydroxymethylglutaryl-CoA reductase activity is essential for mitochondrial β-oxidation of fatty acids to prevent lethal accumulation of long-chain acylcarnitines in the mouse liver.
Liepinsh E, Zvejniece L, Clemensson L, Ozola M, Vavers E, Cirule H, Korzh S, Skuja S, Groma V, Briviba M, Grinberga S, Liu W, Olszewski P, Gentreau M, Fredriksson R, Dambrova M, Schiöth HB. Liepinsh E, et al. Br J Pharmacol. 2024 Aug;181(16):2750-2773. doi: 10.1111/bph.16363. Epub 2024 Apr 19. Br J Pharmacol. 2024. PMID: 38641905