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COPI vesicle formation and N-myristoylation are targetable vulnerabilities of senescent cells.
McHugh D, Sun B, Gutierrez-Muñoz C, Hernández-González F, Mellone M, Guiho R, Duran I, Pombo J, Pietrocola F, Birch J, Kallemeijn WW, Khadayate S, Dharmalingam G, Vernia S, Tate EW, Martínez-Barbera JP, Withers DJ, Thomas GJ, Serrano M, Gil J. McHugh D, et al. Nat Cell Biol. 2023 Dec;25(12):1804-1820. doi: 10.1038/s41556-023-01287-6. Epub 2023 Nov 27. Nat Cell Biol. 2023. PMID: 38012402 Free PMC article.
Cardiac glycosides are broad-spectrum senolytics.
Guerrero A, Herranz N, Sun B, Wagner V, Gallage S, Guiho R, Wolter K, Pombo J, Irvine EE, Innes AJ, Birch J, Glegola J, Manshaei S, Heide D, Dharmalingam G, Harbig J, Olona A, Behmoaras J, Dauch D, Uren AG, Zender L, Vernia S, Martínez-Barbera JP, Heikenwalder M, Withers DJ, Gil J. Guerrero A, et al. Nat Metab. 2019 Nov;1(11):1074-1088. doi: 10.1038/s42255-019-0122-z. Epub 2019 Oct 21. Nat Metab. 2019. PMID: 31799499 Free PMC article.
XPO7 is a tumor suppressor regulating p21CIP1-dependent senescence.
Innes AJ, Sun B, Wagner V, Brookes S, McHugh D, Pombo J, Porreca RM, Dharmalingam G, Vernia S, Zuber J, Vannier JB, García-Escudero R, Gil J. Innes AJ, et al. Genes Dev. 2021 Mar 1;35(5-6):379-391. doi: 10.1101/gad.343269.120. Epub 2021 Feb 18. Genes Dev. 2021. PMID: 33602872 Free PMC article.