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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.
Howard DM, Adams MJ, Clarke TK, Hafferty JD, Gibson J, Shirali M, Coleman JRI, Hagenaars SP, Ward J, Wigmore EM, Alloza C, Shen X, Barbu MC, Xu EY, Whalley HC, Marioni RE, Porteous DJ, Davies G, Deary IJ, Hemani G, Berger K, Teismann H, Rawal R, Arolt V, Baune BT, Dannlowski U, Domschke K, Tian C, Hinds DA; 23andMe Research Team; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; Trzaskowski M, Byrne EM, Ripke S, Smith DJ, Sullivan PF, Wray NR, Breen G, Lewis CM, McIntosh AM. Howard DM, et al. Nat Neurosci. 2019 Mar;22(3):343-352. doi: 10.1038/s41593-018-0326-7. Epub 2019 Feb 4. Nat Neurosci. 2019. PMID: 30718901 Free PMC article.
Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores.
Vilhjálmsson BJ, Yang J, Finucane HK, Gusev A, Lindström S, Ripke S, Genovese G, Loh PR, Bhatia G, Do R, Hayeck T, Won HH; Schizophrenia Working Group of the Psychiatric Genomics Consortium, Discovery, Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE) study; Kathiresan S, Pato M, Pato C, Tamimi R, Stahl E, Zaitlen N, Pasaniuc B, Belbin G, Kenny EE, Schierup MH, De Jager P, Patsopoulos NA, McCarroll S, Daly M, Purcell S, Chasman D, Neale B, Goddard M, Visscher PM, Kraft P, Patterson N, Price AL. Vilhjálmsson BJ, et al. Am J Hum Genet. 2015 Oct 1;97(4):576-92. doi: 10.1016/j.ajhg.2015.09.001. Am J Hum Genet. 2015. PMID: 26430803 Free PMC article.
Gene-environment correlations and causal effects of childhood maltreatment on physical and mental health: a genetically informed approach.
Warrier V, Kwong ASF, Luo M, Dalvie S, Croft J, Sallis HM, Baldwin J, Munafò MR, Nievergelt CM, Grant AJ, Burgess S, Moore TM, Barzilay R, McIntosh A, van IJzendoorn MH, Cecil CAM. Warrier V, et al. Lancet Psychiatry. 2021 May;8(5):373-386. doi: 10.1016/S2215-0366(20)30569-1. Epub 2021 Mar 16. Lancet Psychiatry. 2021. PMID: 33740410 Free PMC article.
Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group.
Schmaal L, Hibar DP, Sämann PG, Hall GB, Baune BT, Jahanshad N, Cheung JW, van Erp TGM, Bos D, Ikram MA, Vernooij MW, Niessen WJ, Tiemeier H, Hofman A, Wittfeld K, Grabe HJ, Janowitz D, Bülow R, Selonke M, Völzke H, Grotegerd D, Dannlowski U, Arolt V, Opel N, Heindel W, Kugel H, Hoehn D, Czisch M, Couvy-Duchesne B, Rentería ME, Strike LT, Wright MJ, Mills NT, de Zubicaray GI, McMahon KL, Medland SE, Martin NG, Gillespie NA, Goya-Maldonado R, Gruber O, Krämer B, Hatton SN, Lagopoulos J, Hickie IB, Frodl T, Carballedo A, Frey EM, van Velzen LS, Penninx BWJH, van Tol MJ, van der Wee NJ, Davey CG, Harrison BJ, Mwangi B, Cao B, Soares JC, Veer IM, Walter H, Schoepf D, Zurowski B, Konrad C, Schramm E, Normann C, Schnell K, Sacchet MD, Gotlib IH, MacQueen GM, Godlewska BR, Nickson T, McIntosh AM, Papmeyer M, Whalley HC, Hall J, Sussmann JE, Li M, Walter M, Aftanas L, Brack I, Bokhan NA, Thompson PM, Veltman DJ. Schmaal L, et al. Mol Psychiatry. 2017 Jun;22(6):900-909. doi: 10.1038/mp.2016.60. Epub 2016 May 3. Mol Psychiatry. 2017. PMID: 27137745 Free PMC article.
Associations between alcohol use and accelerated biological ageing.
Bøstrand SMK, Vaher K, de Nooij L, Harris MA, Cole JH, Cox SR, Marioni RE, McCartney DL, Walker RM, McIntosh AM, Evans KL, Whalley HC, Wootton RE, Clarke TK. Bøstrand SMK, et al. Addict Biol. 2022 Jan;27(1):e13100. doi: 10.1111/adb.13100. Epub 2021 Oct 12. Addict Biol. 2022. PMID: 34636470 Free PMC article.
Epigenetic Contributions to Clinical Risk Prediction of Cardiovascular Disease.
Chybowska AD, Gadd DA, Cheng Y, Bernabeu E, Campbell A, Walker RM, McIntosh AM, Wrobel N, Murphy L, Welsh P, Sattar N, Price JF, McCartney DL, Evans KL, Marioni RE. Chybowska AD, et al. Circ Genom Precis Med. 2024 Feb;17(1):e004265. doi: 10.1161/CIRCGEN.123.004265. Epub 2024 Jan 30. Circ Genom Precis Med. 2024. PMID: 38288591 Free PMC article.
Novel genetic loci associated with hippocampal volume.
Hibar DP, Adams HHH, Jahanshad N, Chauhan G, Stein JL, Hofer E, Renteria ME, Bis JC, Arias-Vasquez A, Ikram MK, Desrivières S, Vernooij MW, Abramovic L, Alhusaini S, Amin N, Andersson M, Arfanakis K, Aribisala BS, Armstrong NJ, Athanasiu L, Axelsson T, Beecham AH, Beiser A, Bernard M, Blanton SH, Bohlken MM, Boks MP, Bralten J, Brickman AM, Carmichael O, Chakravarty MM, Chen Q, Ching CRK, Chouraki V, Cuellar-Partida G, Crivello F, Den Braber A, Doan NT, Ehrlich S, Giddaluru S, Goldman AL, Gottesman RF, Grimm O, Griswold ME, Guadalupe T, Gutman BA, Hass J, Haukvik UK, Hoehn D, Holmes AJ, Hoogman M, Janowitz D, Jia T, Jørgensen KN, Karbalai N, Kasperaviciute D, Kim S, Klein M, Kraemer B, Lee PH, Liewald DCM, Lopez LM, Luciano M, Macare C, Marquand AF, Matarin M, Mather KA, Mattheisen M, McKay DR, Milaneschi Y, Muñoz Maniega S, Nho K, Nugent AC, Nyquist P, Loohuis LMO, Oosterlaan J, Papmeyer M, Pirpamer L, Pütz B, Ramasamy A, Richards JS, Risacher SL, Roiz-Santiañez R, Rommelse N, Ropele S, Rose EJ, Royle NA, Rundek T, Sämann PG, Saremi A, Satizabal CL, Schmaal L, Schork AJ, Shen L, Shin J, Shumskaya E, Smith AV, Sprooten E, Strike LT, Teumer A, Tordesillas-Gutierrez D, Toro R, Trabz… See abstract for full author list ➔ Hibar DP, et al. Nat Commun. 2017 Jan 18;8:13624. doi: 10.1038/ncomms13624. Nat Commun. 2017. PMID: 28098162 Free PMC article.
Genome-wide interaction study with major depression identifies novel variants associated with cognitive function.
Thalamuthu A, Mills NT, Berger K, Minnerup H, Grotegerd D, Dannlowski U, Meinert S, Opel N, Repple J, Gruber M, Nenadić I, Stein F, Brosch K, Meller T, Pfarr JK, Forstner AJ, Hoffmann P, Nöthen MM, Witt S, Rietschel M, Kircher T, Adams M, McIntosh AM, Porteous DJ, Deary IJ, Hayward C, Campbell A, Grabe HJ, Teumer A, Homuth G, van der Auwera-Palitschka S, Schubert KO, Baune BT. Thalamuthu A, et al. Mol Psychiatry. 2022 Feb;27(2):1111-1119. doi: 10.1038/s41380-021-01379-5. Epub 2021 Nov 15. Mol Psychiatry. 2022. PMID: 34782712 Free PMC article.
49 results