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2021 7
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Page 1
Mapping the proteo-genomic convergence of human diseases.
Pietzner M, Wheeler E, Carrasco-Zanini J, Cortes A, Koprulu M, Wörheide MA, Oerton E, Cook J, Stewart ID, Kerrison ND, Luan J, Raffler J, Arnold M, Arlt W, O'Rahilly S, Kastenmüller G, Gamazon ER, Hingorani AD, Scott RA, Wareham NJ, Langenberg C. Pietzner M, et al. Science. 2021 Nov 12;374(6569):eabj1541. doi: 10.1126/science.abj1541. Epub 2021 Nov 12. Science. 2021. PMID: 34648354 Free PMC article.
Therapeutic Targets for Heart Failure Identified Using Proteomics and Mendelian Randomization.
Henry A, Gordillo-Marañón M, Finan C, Schmidt AF, Ferreira JP, Karra R, Sundström J, Lind L, Ärnlöv J, Zannad F, Mälarstig A, Hingorani AD, Lumbers RT; HERMES and SCALLOP Consortia. Henry A, et al. Circulation. 2022 Apr 19;145(16):1205-1217. doi: 10.1161/CIRCULATIONAHA.121.056663. Epub 2022 Mar 18. Circulation. 2022. PMID: 35300523 Free PMC article.
Identifying and visualising multimorbidity and comorbidity patterns in patients in the English National Health Service: a population-based study.
Kuan V, Denaxas S, Patalay P, Nitsch D, Mathur R, Gonzalez-Izquierdo A, Sofat R, Partridge L, Roberts A, Wong ICK, Hingorani M, Chaturvedi N, Hemingway H, Hingorani AD; Multimorbidity Mechanism and Therapeutic Research Collaborative (MMTRC). Kuan V, et al. Lancet Digit Health. 2023 Jan;5(1):e16-e27. doi: 10.1016/S2589-7500(22)00187-X. Epub 2022 Nov 29. Lancet Digit Health. 2023. PMID: 36460578 Free article.
Proteogenomic links to human metabolic diseases.
Koprulu M, Carrasco-Zanini J, Wheeler E, Lockhart S, Kerrison ND, Wareham NJ, Pietzner M, Langenberg C. Koprulu M, et al. Nat Metab. 2023 Mar;5(3):516-528. doi: 10.1038/s42255-023-00753-7. Epub 2023 Feb 23. Nat Metab. 2023. PMID: 36823471 Free PMC article.
Utility of polygenic risk scores in UK cancer screening: a modelling analysis.
Huntley C, Torr B, Sud A, Rowlands CF, Way R, Snape K, Hanson H, Swanton C, Broggio J, Lucassen A, McCartney M, Houlston RS, Hingorani AD, Jones ME, Turnbull C. Huntley C, et al. Lancet Oncol. 2023 Jun;24(6):658-668. doi: 10.1016/S1470-2045(23)00156-0. Epub 2023 May 10. Lancet Oncol. 2023. PMID: 37178708 Free article. Review.
Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death: A Mendelian randomisation study.
Hamilton FW, Thomas M, Arnold D, Palmer T, Moran E, Mentzer AJ, Maskell N, Baillie K, Summers C, Hingorani A, MacGowan A, Khandaker GM, Mitchell R, Davey Smith G, Ghazal P, Timpson NJ. Hamilton FW, et al. PLoS Med. 2023 Jan 30;20(1):e1004174. doi: 10.1371/journal.pmed.1004174. eCollection 2023 Jan. PLoS Med. 2023. PMID: 36716318 Free PMC article.
Druggable proteins influencing cardiac structure and function: Implications for heart failure therapies and cancer cardiotoxicity.
Schmidt AF, Bourfiss M, Alasiri A, Puyol-Anton E, Chopade S, van Vugt M, van der Laan SW, Gross C, Clarkson C, Henry A, Lumbers TR, van der Harst P, Franceschini N, Bis JC, Velthuis BK, Te Riele ASJM, Hingorani AD, Ruijsink B, Asselbergs FW, van Setten J, Finan C. Schmidt AF, et al. Sci Adv. 2023 Apr 28;9(17):eadd4984. doi: 10.1126/sciadv.add4984. Epub 2023 Apr 26. Sci Adv. 2023. PMID: 37126556 Free PMC article.
30 results