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NADP(H)-dependent biocatalysis without adding NADP(H).
Herold RA, Reinbold R, Schofield CJ, Armstrong FA. Herold RA, et al. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2214123120. doi: 10.1073/pnas.2214123120. Epub 2022 Dec 27. Proc Natl Acad Sci U S A. 2023. PMID: 36574703 Free PMC article.
Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors.
Shishodia S, Demetriades M, Zhang D, Tam NY, Maheswaran P, Clunie-O'Connor C, Tumber A, Leung IKH, Ng YM, Leissing TM, El-Sagheer AH, Salah E, Brown T, Aik WS, McDonough MA, Schofield CJ. Shishodia S, et al. J Med Chem. 2021 Nov 25;64(22):16609-16625. doi: 10.1021/acs.jmedchem.1c01204. Epub 2021 Nov 11. J Med Chem. 2021. PMID: 34762429 Free PMC article.
First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53.
Nowak RP, Tumber A, Hendrix E, Ansari MSZ, Sabatino M, Antonini L, Andrijes R, Salah E, Mautone N, Pellegrini FR, Simelis K, Kawamura A, Johansson C, Passeri D, Pellicciari R, Ciogli A, Del Bufalo D, Ragno R, Coleman ML, Trisciuoglio D, Mai A, Oppermann U, Schofield CJ, Rotili D. Nowak RP, et al. J Med Chem. 2021 Dec 9;64(23):17031-17050. doi: 10.1021/acs.jmedchem.1c00605. Epub 2021 Nov 29. J Med Chem. 2021. PMID: 34843649 Free PMC article.
JMJD6 Is a Druggable Oxygenase That Regulates AR-V7 Expression in Prostate Cancer.
Paschalis A, Welti J, Neeb AJ, Yuan W, Figueiredo I, Pereira R, Ferreira A, Riisnaes R, Rodrigues DN, Jiménez-Vacas JM, Kim S, Uo T, Micco PD, Tumber A, Islam MS, Moesser MA, Abboud M, Kawamura A, Gurel B, Christova R, Gil VS, Buroni L, Crespo M, Miranda S, Lambros MB, Carreira S, Tunariu N, Alimonti A, Al-Lazikani B, Schofield CJ, Plymate SR, Sharp A, de Bono JS; , SU2C/PCF International Prostate Cancer Dream Team. Paschalis A, et al. Cancer Res. 2021 Feb 15;81(4):1087-1100. doi: 10.1158/0008-5472.CAN-20-1807. Cancer Res. 2021. PMID: 33822745 Free PMC article.
51 results