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ABT-378, a highly potent inhibitor of the human immunodeficiency virus protease.
Sham HL, Kempf DJ, Molla A, Marsh KC, Kumar GN, Chen CM, Kati W, Stewart K, Lal R, Hsu A, Betebenner D, Korneyeva M, Vasavanonda S, McDonald E, Saldivar A, Wideburg N, Chen X, Niu P, Park C, Jayanti V, Grabowski B, Granneman GR, Sun E, Japour AJ, Leonard JM, Plattner JJ, Norbeck DW. Sham HL, et al. Among authors: chen cm, chen x. Antimicrob Agents Chemother. 1998 Dec;42(12):3218-24. doi: 10.1128/AAC.42.12.3218. Antimicrob Agents Chemother. 1998. PMID: 9835517 Free PMC article. Clinical Trial.
Novel alpha- and beta-amino acid inhibitors of influenza virus neuraminidase.
Kati WM, Montgomery D, Maring C, Stoll VS, Giranda V, Chen X, Laver WG, Kohlbrenner W, Norbeck DW. Kati WM, et al. Among authors: chen x. Antimicrob Agents Chemother. 2001 Sep;45(9):2563-70. doi: 10.1128/AAC.45.9.2563-2570.2001. Antimicrob Agents Chemother. 2001. PMID: 11502530 Free PMC article.
Neuraminidase inhibitors as anti-influenza virus agents.
Kim CU, Chen X, Mendel DB. Kim CU, et al. Among authors: chen x. Antivir Chem Chemother. 1999 Jul;10(4):141-54. doi: 10.1177/095632029901000401. Antivir Chem Chemother. 1999. PMID: 10480735 Free article. Review.
Structure-based design of parasitic protease inhibitors.
Li R, Chen X, Gong B, Selzer PM, Li Z, Davidson E, Kurzban G, Miller RE, Nuzum EO, McKerrow JH, Fletterick RJ, Gillmor SA, Craik CS, Kuntz ID, Cohen FE, Kenyon GL. Li R, et al. Among authors: chen x. Bioorg Med Chem. 1996 Sep;4(9):1421-7. doi: 10.1016/0968-0896(96)00136-8. Bioorg Med Chem. 1996. PMID: 8894100 Free article.
Development of potent and selective factor Xa inhibitors.
Rai R, Kolesnikov A, Li Y, Young WB, Leahy E, Sprengeler PA, Verner E, Shrader WD, Burgess-Henry J, Sangalang JC, Allen D, Chen X, Katz BA, Luong C, Elrod K, Cregar L. Rai R, et al. Among authors: chen x. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1797-800. doi: 10.1016/s0960-894x(01)00311-0. Bioorg Med Chem Lett. 2001. PMID: 11459634
Potent pyrrolidine- and piperidine-based BACE-1 inhibitors.
Iserloh U, Wu Y, Cumming JN, Pan J, Wang LY, Stamford AW, Kennedy ME, Kuvelkar R, Chen X, Parker EM, Strickland C, Voigt J. Iserloh U, et al. Among authors: chen x. Bioorg Med Chem Lett. 2008 Jan 1;18(1):414-7. doi: 10.1016/j.bmcl.2007.10.116. Epub 2007 Nov 6. Bioorg Med Chem Lett. 2008. PMID: 18023580
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