Presta LG - Search Results

1

An efficient route to human bispecific IgG.

Merchant AM, Zhu Z, Yuan JQ, Goddard A, Adams CW, Presta LG, Carter P. Merchant AM, et al. Among authors: presta lg. Nat Biotechnol. 1998 Jul;16(7):677-81. doi: 10.1038/nbt0798-677. Nat Biotechnol. 1998. PMID: 9661204

2

'Knobs-into-holes' engineering of antibody CH3 domains for heavy chain heterodimerization.

Ridgway JB, Presta LG, Carter P. Ridgway JB, et al. Among authors: presta lg. Protein Eng. 1996 Jul;9(7):617-21. doi: 10.1093/protein/9.7.617. Protein Eng. 1996. PMID: 8844834

3

Remodeling domain interfaces to enhance heterodimer formation.

Zhu Z, Presta LG, Zapata G, Carter P. Zhu Z, et al. Among authors: presta lg. Protein Sci. 1997 Apr;6(4):781-8. doi: 10.1002/pro.5560060404. Protein Sci. 1997. PMID: 9098887 Free PMC article.

4

Development of humanized bispecific antibodies reactive with cytotoxic lymphocytes and tumor cells overexpressing the HER2 protooncogene.

Shalaby MR, Shepard HM, Presta L, Rodrigues ML, Beverley PC, Feldmann M, Carter P. Shalaby MR, et al. J Exp Med. 1992 Jan 1;175(1):217-25. doi: 10.1084/jem.175.1.217. J Exp Med. 1992. PMID: 1346155 Free PMC article.

5

Engineering a humanized bispecific F(ab')2 fragment for improved binding to T cells.

Rodrigues ML, Shalaby MR, Werther W, Presta L, Carter P. Rodrigues ML, et al. Int J Cancer Suppl. 1992;7:45-50. Int J Cancer Suppl. 1992. PMID: 1428403

6

X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling.

Eigenbrot C, Randal M, Presta L, Carter P, Kossiakoff AA. Eigenbrot C, et al. J Mol Biol. 1993 Feb 20;229(4):969-95. doi: 10.1006/jmbi.1993.1099. J Mol Biol. 1993. PMID: 8095303

7

Humanization of a recombinant monoclonal antibody to produce a therapeutic HER dimerization inhibitor, pertuzumab.

Adams CW, Allison DE, Flagella K, Presta L, Clarke J, Dybdal N, McKeever K, Sliwkowski MX. Adams CW, et al. Cancer Immunol Immunother. 2006 Jun;55(6):717-27. doi: 10.1007/s00262-005-0058-x. Epub 2005 Sep 3. Cancer Immunol Immunother. 2006. PMID: 16151804 Free PMC article.

8

Comprehensive functional maps of the antigen-binding site of an anti-ErbB2 antibody obtained with shotgun scanning mutagenesis.

Vajdos FF, Adams CW, Breece TN, Presta LG, de Vos AM, Sidhu SS. Vajdos FF, et al. Among authors: presta lg. J Mol Biol. 2002 Jul 5;320(2):415-28. doi: 10.1016/S0022-2836(02)00264-4. J Mol Biol. 2002. PMID: 12079396

9

Humanization of an anti-p185HER2 antibody for human cancer therapy.

Carter P, Presta L, Gorman CM, Ridgway JB, Henner D, Wong WL, Rowland AM, Kotts C, Carver ME, Shepard HM. Carter P, et al. Proc Natl Acad Sci U S A. 1992 May 15;89(10):4285-9. doi: 10.1073/pnas.89.10.4285. Proc Natl Acad Sci U S A. 1992. PMID: 1350088 Free PMC article.

10

Development of a humanized disulfide-stabilized anti-p185HER2 Fv-beta-lactamase fusion protein for activation of a cephalosporin doxorubicin prodrug.

Rodrigues ML, Presta LG, Kotts CE, Wirth C, Mordenti J, Osaka G, Wong WL, Nuijens A, Blackburn B, Carter P. Rodrigues ML, et al. Among authors: presta lg. Cancer Res. 1995 Jan 1;55(1):63-70. Cancer Res. 1995. PMID: 7805042

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