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Identification of a 190-kDa protein as a novel substrate for the insulin receptor kinase functionally similar to insulin receptor substrate-1.
Tobe K, Tamemoto H, Yamauchi T, Aizawa S, Yazaki Y, Kadowaki T. Tobe K, et al. Among authors: yazaki y. J Biol Chem. 1995 Mar 17;270(11):5698-701. doi: 10.1074/jbc.270.11.5698. J Biol Chem. 1995. PMID: 7534300 Free article.
Recently, we generated mice with a targeted disruption of the insulin receptor substrate-1 (IRS-1) gene and demonstrated that they exhibited growth retardation and mild insulin resistance, suggesting the presence of IRS-1-independent pathway that partially substitutes for IRS-1 i …
Recently, we generated mice with a targeted disruption of the insulin receptor substrate-1 (IRS-1) gene and demonstrated that they exhibited …
Mutant of insulin receptor substrate-1 incapable of activating phosphatidylinositol 3-kinase did not mediate insulin-stimulated maturation of Xenopus laevis oocytes.
Yamamoto-Honda R, Honda Z, Ueki K, Tobe K, Kaburagi Y, Takahashi Y, Tamemoto H, Suzuki T, Itoh K, Akanuma Y, Yazaki Y, Kadowaki T. Yamamoto-Honda R, et al. Among authors: yazaki y. J Biol Chem. 1996 Nov 8;271(45):28677-81. doi: 10.1074/jbc.271.45.28677. J Biol Chem. 1996. PMID: 8910502 Free article.
Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease.
Terauchi Y, Iwamoto K, Tamemoto H, Komeda K, Ishii C, Kanazawa Y, Asanuma N, Aizawa T, Akanuma Y, Yasuda K, Kodama T, Tobe K, Yazaki Y, Kadowaki T. Terauchi Y, et al. Among authors: yazaki y. J Clin Invest. 1997 Mar 1;99(5):861-6. doi: 10.1172/JCI119250. J Clin Invest. 1997. PMID: 9062343 Free PMC article.
Signal transduction mechanism of insulin and insulin-like growth factor-1.
Kadowaki T, Tobe K, Honda-Yamamoto R, Tamemoto H, Kaburagi Y, Momomura K, Ueki K, Takahashi Y, Yamauchi T, Akanuma Y, Yazaki Y. Kadowaki T, et al. Among authors: yazaki y. Endocr J. 1996 Oct;43 Suppl:S33-41. doi: 10.1507/endocrj.43.suppl_s33. Endocr J. 1996. PMID: 9076340 Free article. Review.
Role of insulin receptor substrate-1 and pp60 in the regulation of insulin-induced glucose transport and GLUT4 translocation in primary adipocytes.
Kaburagi Y, Satoh S, Tamemoto H, Yamamoto-Honda R, Tobe K, Veki K, Yamauchi T, Kono-Sugita E, Sekihara H, Aizawa S, Cushman SW, Akanuma Y, Yazaki Y, Kadowaki T. Kaburagi Y, et al. Among authors: yazaki y. J Biol Chem. 1997 Oct 10;272(41):25839-44. doi: 10.1074/jbc.272.41.25839. J Biol Chem. 1997. PMID: 9325314 Free article.
To study the role of these endogenous substrates in glucose transport, we analyzed adipocytes from IRS-1 null mice that we previously generated (Tamemoto, H., Kadowaki, T., Tobe, K., Yagi, T., Sakura, H., Hayakawa, T., Terauchi, Y., Ueki, K., Kaburagi, Y., Satoh, S. …
To study the role of these endogenous substrates in glucose transport, we analyzed adipocytes from IRS-1 null mice that we previously genera …
Growth hormone and prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1, -2, and -3, their association with p85 phosphatidylinositol 3-kinase (PI3-kinase), and concomitantly PI3-kinase activation via JAK2 kinase.
Yamauchi T, Kaburagi Y, Ueki K, Tsuji Y, Stark GR, Kerr IM, Tsushima T, Akanuma Y, Komuro I, Tobe K, Yazaki Y, Kadowaki T. Yamauchi T, et al. Among authors: yazaki y. J Biol Chem. 1998 Jun 19;273(25):15719-26. doi: 10.1074/jbc.273.25.15719. J Biol Chem. 1998. PMID: 9624169 Free article.
1,085 results