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Phase I trial of intranasal and endobronchial administration of a recombinant adeno-associated virus serotype 2 (rAAV2)-CFTR vector in adult cystic fibrosis patients: a two-part clinical study.
Flotte TR, Zeitlin PL, Reynolds TC, Heald AE, Pedersen P, Beck S, Conrad CK, Brass-Ernst L, Humphries M, Sullivan K, Wetzel R, Taylor G, Carter BJ, Guggino WB. Flotte TR, et al. Among authors: reynolds tc. Hum Gene Ther. 2003 Jul 20;14(11):1079-88. doi: 10.1089/104303403322124792. Hum Gene Ther. 2003. PMID: 12885347 Clinical Trial.
In vivo model of adeno-associated virus vector persistence and rescue.
Afione SA, Conrad CK, Kearns WG, Chunduru S, Adams R, Reynolds TC, Guggino WB, Cutting GR, Carter BJ, Flotte TR. Afione SA, et al. Among authors: reynolds tc. J Virol. 1996 May;70(5):3235-41. doi: 10.1128/JVI.70.5.3235-3241.1996. J Virol. 1996. PMID: 8627804 Free PMC article.
Repeated delivery of adeno-associated virus vectors to the rabbit airway.
Beck SE, Jones LA, Chesnut K, Walsh SM, Reynolds TC, Carter BJ, Askin FB, Flotte TR, Guggino WB. Beck SE, et al. Among authors: reynolds tc. J Virol. 1999 Nov;73(11):9446-55. doi: 10.1128/JVI.73.11.9446-9455.1999. J Virol. 1999. PMID: 10516053 Free PMC article.
A phase II, double-blind, randomized, placebo-controlled clinical trial of tgAAVCF using maxillary sinus delivery in patients with cystic fibrosis with antrostomies.
Wagner JA, Nepomuceno IB, Messner AH, Moran ML, Batson EP, Dimiceli S, Brown BW, Desch JK, Norbash AM, Conrad CK, Guggino WB, Flotte TR, Wine JJ, Carter BJ, Reynolds TC, Moss RB, Gardner P. Wagner JA, et al. Among authors: reynolds tc. Hum Gene Ther. 2002 Jul 20;13(11):1349-59. doi: 10.1089/104303402760128577. Hum Gene Ther. 2002. PMID: 12162817 Clinical Trial.
Safety and biological efficacy of an adeno-associated virus vector-cystic fibrosis transmembrane regulator (AAV-CFTR) in the cystic fibrosis maxillary sinus.
Wagner JA, Messner AH, Moran ML, Daifuku R, Kouyama K, Desch JK, Manley S, Norbash AM, Conrad CK, Friborg S, Reynolds T, Guggino WB, Moss RB, Carter BJ, Wine JJ, Flotte TR, Gardner P. Wagner JA, et al. Laryngoscope. 1999 Feb;109(2 Pt 1):266-74. doi: 10.1097/00005537-199902000-00017. Laryngoscope. 1999. PMID: 10890777 Clinical Trial.
30 results