Watson KA - Search Results

1

N-acetyl-beta-D-glucopyranosylamine: a potent T-state inhibitor of glycogen phosphorylase. A comparison with alpha-D-glucose.

Oikonomakos NG, Kontou M, Zographos SE, Watson KA, Johnson LN, Bichard CJ, Fleet GW, Acharya KR. Oikonomakos NG, et al. Among authors: watson ka. Protein Sci. 1995 Dec;4(12):2469-77. doi: 10.1002/pro.5560041203. Protein Sci. 1995. PMID: 8580837 Free PMC article.

2

The design of potential antidiabetic drugs: experimental investigation of a number of beta-D-glucose analogue inhibitors of glycogen phosphorylase.

Oikonomakos NG, Kontou M, Zographos SE, Tsitoura HS, Johnson LN, Watson KA, Mitchell EP, Fleet GW, Son JC, Bichard CJ, et al. Oikonomakos NG, et al. Among authors: watson ka. Eur J Drug Metab Pharmacokinet. 1994 Jul-Sep;19(3):185-92. doi: 10.1007/BF03188920. Eur J Drug Metab Pharmacokinet. 1994. PMID: 7867660

3

The structure of glycogen phosphorylase b with an alkyldihydropyridine-dicarboxylic acid compound, a novel and potent inhibitor.

Zographos SE, Oikonomakos NG, Tsitsanou KE, Leonidas DD, Chrysina ED, Skamnaki VT, Bischoff H, Goldmann S, Watson KA, Johnson LN. Zographos SE, et al. Among authors: watson ka. Structure. 1997 Nov 15;5(11):1413-25. doi: 10.1016/s0969-2126(97)00292-x. Structure. 1997. PMID: 9384557 Free article.

4

The structure of a glycogen phosphorylase glucopyranose spirohydantoin complex at 1.8 A resolution and 100 K: the role of the water structure and its contribution to binding.

Gregoriou M, Noble ME, Watson KA, Garman EF, Krulle TM, de la Fuente C, Fleet GW, Oikonomakos NG, Johnson LN. Gregoriou M, et al. Among authors: watson ka. Protein Sci. 1998 Apr;7(4):915-27. doi: 10.1002/pro.5560070409. Protein Sci. 1998. PMID: 9568898 Free PMC article.

5

Effects of commonly used cryoprotectants on glycogen phosphorylase activity and structure.

Tsitsanou KE, Oikonomakos NG, Zographos SE, Skamnaki VT, Gregoriou M, Watson KA, Johnson LN, Fleet GW. Tsitsanou KE, et al. Among authors: watson ka. Protein Sci. 1999 Apr;8(4):741-9. doi: 10.1110/ps.8.4.741. Protein Sci. 1999. PMID: 10211820 Free PMC article.

6

Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase.

Watson KA, Chrysina ED, Tsitsanou KE, Zographos SE, Archontis G, Fleet GW, Oikonomakos NG. Watson KA, et al. Proteins. 2005 Dec 1;61(4):966-83. doi: 10.1002/prot.20653. Proteins. 2005. PMID: 16222658

7

Design of inhibitors of glycogen phosphorylase: a study of alpha- and beta-C-glucosides and 1-thio-beta-D-glucose compounds.

Watson KA, Mitchell EP, Johnson LN, Son JC, Bichard CJ, Orchard MG, Fleet GW, Oikonomakos NG, Leonidas DD, Kontou M, et al. Watson KA, et al. Biochemistry. 1994 May 17;33(19):5745-58. doi: 10.1021/bi00185a011. Biochemistry. 1994. PMID: 8180201

8

Glucose analogue inhibitors of glycogen phosphorylase: from crystallographic analysis to drug prediction using GRID force-field and GOLPE variable selection.

Watson KA, Mitchell EP, Johnson LN, Cruciani G, Son JC, Bichard CJ, Fleet GW, Oikonomakos NG, Kontou M, Zographos SE. Watson KA, et al. Acta Crystallogr D Biol Crystallogr. 1995 Jul 1;51(Pt 4):458-72. doi: 10.1107/S090744499401348X. Acta Crystallogr D Biol Crystallogr. 1995. PMID: 15299833

9

Glycogen phosphorylase inhibitors: a free energy perturbation analysis of glucopyranose spirohydantoin analogues.

Archontis G, Watson KA, Xie Q, Andreou G, Chrysina ED, Zographos SE, Oikonomakos NG, Karplus M. Archontis G, et al. Among authors: watson ka. Proteins. 2005 Dec 1;61(4):984-98. doi: 10.1002/prot.20641. Proteins. 2005. PMID: 16245298

10

The crystal structure of Escherichia coli maltodextrin phosphorylase provides an explanation for the activity without control in this basic archetype of a phosphorylase.

Watson KA, Schinzel R, Palm D, Johnson LN. Watson KA, et al. EMBO J. 1997 Jan 2;16(1):1-14. doi: 10.1093/emboj/16.1.1. EMBO J. 1997. PMID: 9009262 Free PMC article.

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