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HIV-1 p55Gag encoded in the lysosome-associated membrane protein-1 as a DNA plasmid vaccine chimera is highly expressed, traffics to the major histocompatibility class II compartment, and elicits enhanced immune responses.
Marques ET Jr, Chikhlikar P, de Arruda LB, Leao IC, Lu Y, Wong J, Chen JS, Byrne B, August JT. Marques ET Jr, et al. Among authors: august jt. J Biol Chem. 2003 Sep 26;278(39):37926-36. doi: 10.1074/jbc.M303336200. Epub 2003 Jun 24. J Biol Chem. 2003. PMID: 12824194 Free article.
West Nile premembrane-envelope genetic vaccine encoded as a chimera containing the transmembrane and cytoplasmic domains of a lysosome-associated membrane protein: increased cellular concentration of the transgene product, targeting to the MHC II compartment, and enhanced neutralizing antibody response.
Anwar A, Chandrasekaran A, Ng ML, Marques E, August JT. Anwar A, et al. Among authors: august jt. Virology. 2005 Feb 5;332(1):66-77. doi: 10.1016/j.virol.2004.11.022. Virology. 2005. PMID: 15661141 Free article.
187 results