Conformational states of the nuclear GTP-binding protein Ran and its complexes with the exchange factor RCC1 and the effector protein RanBP1.
Geyer M, Assheuer R, Klebe C, Kuhlmann J, Becker J, Wittinghofer A, Kalbitzer HR.
Geyer M, et al.
Biochemistry. 1999 Aug 31;38(35):11250-60. doi: 10.1021/bi9904306.
Biochemistry. 1999.
PMID: 10471274
It has been shown before by (31)P NMR that Ras bound to the nonhydrolyzable GTP analogue guanosine 5'-O-(beta, gamma-imidotriphosphate) (GppNHp) exists in two conformations which are rapidly interconverting with a rate constant of 3200 s-1 at 30 degrees C [Geyer, M. …
It has been shown before by (31)P NMR that Ras bound to the nonhydrolyzable GTP analogue guanosine 5'-O-(beta, gamma-imidotriphosphate) (Gpp …