Mook RA Jr - Search Results

1

Niclosamide-induced Wnt signaling inhibition in colorectal cancer is mediated by autophagy.

Wang J, Ren XR, Piao H, Zhao S, Osada T, Premont RT, Mook RA Jr, Morse MA, Lyerly HK, Chen W. Wang J, et al. Among authors: mook ra jr. Biochem J. 2019 Feb 8;476(3):535-546. doi: 10.1042/BCJ20180385. Biochem J. 2019. PMID: 30635359 Free PMC article.

2

Identification of novel triazole inhibitors of Wnt/β-catenin signaling based on the Niclosamide chemotype.

Mook RA Jr, Wang J, Ren XR, Piao H, Lyerly HK, Chen W. Mook RA Jr, et al. Bioorg Med Chem Lett. 2019 Jan 15;29(2):317-321. doi: 10.1016/j.bmcl.2018.11.022. Epub 2018 Nov 12. Bioorg Med Chem Lett. 2019. PMID: 30551901 Free PMC article.

3

Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth.

Wang J, Mook RA Jr, Ren XR, Zhang Q, Jing G, Lu M, Spasojevic I, Lyerly HK, Hsu D, Chen W. Wang J, et al. Among authors: mook ra jr. Bioorg Med Chem. 2018 Nov 1;26(20):5435-5442. doi: 10.1016/j.bmc.2018.09.016. Epub 2018 Sep 17. Bioorg Med Chem. 2018. PMID: 30274939 Free PMC article.

4

Niclosamide: Beyond an antihelminthic drug.

Chen W, Mook RA Jr, Premont RT, Wang J. Chen W, et al. Among authors: mook ra jr. Cell Signal. 2018 Jan;41:89-96. doi: 10.1016/j.cellsig.2017.04.001. Epub 2017 Apr 4. Cell Signal. 2018. PMID: 28389414 Free PMC article. Review.

5

Benzimidazole inhibitors from the Niclosamide chemotype inhibit Wnt/β-catenin signaling with selectivity over effects on ATP homeostasis.

Mook RA Jr, Ren XR, Wang J, Piao H, Barak LS, Kim Lyerly H, Chen W. Mook RA Jr, et al. Bioorg Med Chem. 2017 Mar 15;25(6):1804-1816. doi: 10.1016/j.bmc.2017.01.046. Epub 2017 Feb 3. Bioorg Med Chem. 2017. PMID: 28233680 Free PMC article.

6

Discovery of Manassantin A Protein Targets Using Large-Scale Protein Folding and Stability Measurements.

Geer Wallace MA, Kwon DY, Weitzel DH, Lee CT, Stephenson TN, Chi JT, Mook RA Jr, Dewhirst MW, Hong J, Fitzgerald MC. Geer Wallace MA, et al. Among authors: mook ra jr. J Proteome Res. 2016 Aug 5;15(8):2688-96. doi: 10.1021/acs.jproteome.6b00237. Epub 2016 Jul 8. J Proteome Res. 2016. PMID: 27322910 Free PMC article.

7

Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition.

Kwon DY, Lee HE, Weitzel DH, Park K, Lee SH, Lee CT, Stephenson TN, Park H, Fitzgerald MC, Chi JT, Mook RA Jr, Dewhirst MW, Lee YM, Hong J. Kwon DY, et al. Among authors: mook ra jr. J Med Chem. 2015 Oct 8;58(19):7659-71. doi: 10.1021/acs.jmedchem.5b01220. Epub 2015 Sep 22. J Med Chem. 2015. PMID: 26394152 Free PMC article.

8

Structure-activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure.

Mook RA Jr, Wang J, Ren XR, Chen M, Spasojevic I, Barak LS, Lyerly HK, Chen W. Mook RA Jr, et al. Bioorg Med Chem. 2015 Sep 1;23(17):5829-38. doi: 10.1016/j.bmc.2015.07.001. Epub 2015 Aug 10. Bioorg Med Chem. 2015. PMID: 26272032 Free PMC article.

9

Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth.

Ren XR, Wang J, Osada T, Mook RA Jr, Morse MA, Barak LS, Lyerly HK, Chen W. Ren XR, et al. Among authors: mook ra jr. Breast Cancer Res. 2015 Feb 15;17(1):20. doi: 10.1186/s13058-015-0528-9. Breast Cancer Res. 2015. PMID: 25849870 Free PMC article.

10

Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B-Raf-Driven Tumors.

Rheault TR, Stellwagen JC, Adjabeng GM, Hornberger KR, Petrov KG, Waterson AG, Dickerson SH, Mook RA Jr, Laquerre SG, King AJ, Rossanese OW, Arnone MR, Smitheman KN, Kane-Carson LS, Han C, Moorthy GS, Moss KG, Uehling DE. Rheault TR, et al. Among authors: mook ra jr. ACS Med Chem Lett. 2013 Feb 7;4(3):358-62. doi: 10.1021/ml4000063. eCollection 2013 Mar 14. ACS Med Chem Lett. 2013. PMID: 24900673 Free PMC article.

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