Sites of interaction between rod G-protein alpha-subunit and cGMP-phosphodiesterase gamma-subunit. Implications for the phosphodiesterase activation mechanism.
Artemyev NO, Rarick HM, Mills JS, Skiba NP, Hamm HE.
Artemyev NO, et al.
J Biol Chem. 1992 Dec 15;267(35):25067-72.
J Biol Chem. 1992.
PMID: 1334079
Free article.
The Kd for alpha tGTP gamma S.P gamma LY interaction was 36 nM. Addition of 1 microM alpha tGDP had no effect, but in the presence of A1F4-, alpha tGDP increased P gamma LY fluorescence by 85%. ...We demonstrate that an alpha t peptide, alpha t-293-314, which activated PDE …
The Kd for alpha tGTP gamma S.P gamma LY interaction was 36 nM. Addition of 1 microM alpha tGDP had no effect, but in the presence of …