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Co-regulator activity of Mediator of DNA Damage Checkpoint 1 (MDC1) is associated with DNA repair dysfunction and PARP inhibitor sensitivity in lobular carcinoma of the breast.
Sottnik JL, Shackleford MT, Nesiba CS, Richer AL, Swartz JM, Rowland CE, Musick M, Fu R, Opresko PL, Mehrotra S, Hesselberth JR, Diamond JR, Sikora MJ. Sottnik JL, et al. Among authors: opresko pl. bioRxiv [Preprint]. 2024 Dec 6:2023.10.29.564555. doi: 10.1101/2023.10.29.564555. bioRxiv. 2024. PMID: 39677775 Free PMC article. Preprint.
The molecular mechanism for TERRA recruitment and annealing to telomeres.
Wondimagegnhu B, Ma W, Paul T, Liao TW, Lee CY, Sanford S, Opresko PL, Myong S. Wondimagegnhu B, et al. Among authors: opresko pl. Nucleic Acids Res. 2024 Sep 23;52(17):10490-10503. doi: 10.1093/nar/gkae732. Nucleic Acids Res. 2024. PMID: 39189448 Free PMC article.
A persistent variant telomere sequence in a human pedigree.
Hinchie AM, Sanford SL, Loughridge KE, Sutton RM, Parikh AH, Gil Silva AA, Sullivan DI, Chun-On P, Morrell MR, McDyer JF, Opresko PL, Alder JK. Hinchie AM, et al. Among authors: opresko pl. Nat Commun. 2024 Jun 1;15(1):4681. doi: 10.1038/s41467-024-49072-9. Nat Commun. 2024. PMID: 38824190 Free PMC article.
Deregulated DNA ADP-ribosylation impairs telomere replication.
Wondisford AR, Lee J, Lu R, Schuller M, Groslambert J, Bhargava R, Schamus-Haynes S, Cespedes LC, Opresko PL, Pickett HA, Min J, Ahel I, O'Sullivan RJ. Wondisford AR, et al. Among authors: opresko pl. Nat Struct Mol Biol. 2024 May;31(5):791-800. doi: 10.1038/s41594-024-01279-6. Epub 2024 May 7. Nat Struct Mol Biol. 2024. PMID: 38714889 Free PMC article.
Translating the telomeres.
De Rosa M, Opresko PL. De Rosa M, et al. Among authors: opresko pl. Trends Genet. 2023 Aug;39(8):593-595. doi: 10.1016/j.tig.2023.04.009. Epub 2023 May 12. Trends Genet. 2023. PMID: 37179160 Free PMC article.
Assembly path dependence of telomeric DNA compaction by TRF1, TIN2, and SA1.
Liu M, Pan H, Kaur P, Wang LJ, Jin M, Detwiler AC, Opresko PL, Tao YJ, Wang H, Riehn R. Liu M, et al. Among authors: opresko pl. Biophys J. 2023 May 16;122(10):1822-1832. doi: 10.1016/j.bpj.2023.04.014. Epub 2023 Apr 20. Biophys J. 2023. PMID: 37081787 Free PMC article.
98 results