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Navigating from cellular phenotypic screen to clinical candidate: selective targeting of the NLRP3 inflammasome.
Matico R, Grauwen K, Chauhan D, Yu X, Abdiaj I, Adhikary S, Adriaensen I, Aranzazu GM, Alcázar J, Bassi M, Brisse E, Cañellas S, Chaudhuri S, Delgado F, Diéguez-Vázquez A, Du Jardin M, Eastham V, Finley M, Jacobs T, Keustermans K, Kuhn R, Llaveria J, Leenaerts J, Linares ML, Martín ML, Martín-Pérez R, Martínez C, Miller R, Muñoz FM, Muratore ME, Nooyens A, Perez-Benito L, Perrier M, Pietrak B, Serré J, Sharma S, Somers M, Suarez J, Tresadern G, Trabanco AA, Van den Bulck D, Van Gool M, Van Hauwermeiren F, Varghese T, Vega JA, Youssef SA, Edwards MJ, Oehlrich D, Van Opdenbosch N. Matico R, et al. Among authors: van hauwermeiren f. EMBO Mol Med. 2024 Dec 9. doi: 10.1038/s44321-024-00181-4. Online ahead of print. EMBO Mol Med. 2024. PMID: 39653810 Free article.
NLRP3 inflammasome activation and pyroptosis are dispensable for tau pathology.
Paesmans I, Van Kolen K, Vandermeeren M, Shih PY, Wuyts D, Boone F, Garcia Sanchez S, Grauwen K, Van Hauwermeiren F, Van Opdenbosch N, Lamkanfi M, van Loo G, Bottelbergs A. Paesmans I, et al. Among authors: van hauwermeiren f. Front Aging Neurosci. 2024 Sep 24;16:1459134. doi: 10.3389/fnagi.2024.1459134. eCollection 2024. Front Aging Neurosci. 2024. PMID: 39381137 Free PMC article.
GSDMD drives canonical inflammasome-induced neutrophil pyroptosis and is dispensable for NETosis.
Chauhan D, Demon D, Vande Walle L, Paerewijck O, Zecchin A, Bosseler L, Santoni K, Planès R, Ribo S, Fossoul A, Gonçalves A, Van Gorp H, Van Opdenbosch N, Van Hauwermeiren F, Meunier E, Wullaert A, Lamkanfi M. Chauhan D, et al. Among authors: van hauwermeiren f. EMBO Rep. 2022 Oct 6;23(10):e54277. doi: 10.15252/embr.202154277. Epub 2022 Jul 28. EMBO Rep. 2022. PMID: 35899491 Free PMC article.
How to dodge pyroptosis: lessons from Shigella flexneri.
Van Hauwermeiren F, Lamkanfi M. Van Hauwermeiren F, et al. Cell Res. 2022 Mar;32(3):227-228. doi: 10.1038/s41422-021-00607-5. Cell Res. 2022. PMID: 34934194 Free PMC article. No abstract available.
Correction: MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition.
Walle LV, Stowe IB, Šácha P, Lee BL, Demon D, Fossoul A, Van Hauwermeiren F, Saavedra PHV, Šimon P, Šubr V, Kostka L, Stivala CE, Pham VC, Staben ST, Yamazoe S, Konvalinka J, Kayagaki N, Lamkanfi M. Walle LV, et al. Among authors: van hauwermeiren f. PLoS Biol. 2019 Oct 16;17(10):e3000529. doi: 10.1371/journal.pbio.3000529. eCollection 2019 Oct. PLoS Biol. 2019. PMID: 31618263 Free PMC article.
MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition.
Vande Walle L, Stowe IB, Šácha P, Lee BL, Demon D, Fossoul A, Van Hauwermeiren F, Saavedra PHV, Šimon P, Šubrt V, Kostka L, Stivala CE, Pham VC, Staben ST, Yamazoe S, Konvalinka J, Kayagaki N, Lamkanfi M. Vande Walle L, et al. Among authors: van hauwermeiren f. PLoS Biol. 2019 Sep 16;17(9):e3000354. doi: 10.1371/journal.pbio.3000354. eCollection 2019 Sep. PLoS Biol. 2019. PMID: 31525186 Free PMC article.
35 results