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Navigating from cellular phenotypic screen to clinical candidate: selective targeting of the NLRP3 inflammasome.
Matico R, Grauwen K, Chauhan D, Yu X, Abdiaj I, Adhikary S, Adriaensen I, Aranzazu GM, Alcázar J, Bassi M, Brisse E, Cañellas S, Chaudhuri S, Delgado F, Diéguez-Vázquez A, Du Jardin M, Eastham V, Finley M, Jacobs T, Keustermans K, Kuhn R, Llaveria J, Leenaerts J, Linares ML, Martín ML, Martín-Pérez R, Martínez C, Miller R, Muñoz FM, Muratore ME, Nooyens A, Perez-Benito L, Perrier M, Pietrak B, Serré J, Sharma S, Somers M, Suarez J, Tresadern G, Trabanco AA, Van den Bulck D, Van Gool M, Van Hauwermeiren F, Varghese T, Vega JA, Youssef SA, Edwards MJ, Oehlrich D, Van Opdenbosch N. Matico R, et al. Among authors: van gool m. EMBO Mol Med. 2024 Dec 9. doi: 10.1038/s44321-024-00181-4. Online ahead of print. EMBO Mol Med. 2024. PMID: 39653810 Free article.
Intrathecal IgG and IgM synthesis correlates with neurodegeneration markers and corresponds to meningeal B cell presence in MS.
Rodriguez-Mogeda C, van Gool MM, van der Mast R, Nijland R, Keasberry Z, van de Bovekamp L, van Delft MA, Picon C, Reynolds R, Killestein J, Teunissen CE, de Vries HE, van Egmond M, Witte ME. Rodriguez-Mogeda C, et al. Among authors: van gool mm. Sci Rep. 2024 Oct 26;14(1):25540. doi: 10.1038/s41598-024-76969-8. Sci Rep. 2024. PMID: 39462090 Free PMC article.
Discovery of 6,7-Dihydropyrazolo[1,5-a]pyrazin-4(5H)-one Derivatives as mGluR2 Negative Allosteric Modulators with In Vivo Activity in a Rodent's Model of Cognition.
Alonso de Diego SA, Linares ML, García Molina A, de Lucas AI, Del Cerro A, Alonso JM, Ver Donck L, Cid JM, Trabanco AA, Van Gool M. Alonso de Diego SA, et al. Among authors: van gool m. J Med Chem. 2024 Sep 12;67(17):15569-15585. doi: 10.1021/acs.jmedchem.4c01227. Epub 2024 Aug 29. J Med Chem. 2024. PMID: 39208150
A flexible, image-based, high-throughput platform encompassing in-depth cell profiling to identify broad-spectrum coronavirus antivirals with limited off-target effects.
Doijen J, Heo I, Temmerman K, Vermeulen P, Diels A, Jaensch S, Burcin M, Van den Broeck N, Raeymaekers V, Peremans J, Konings K, Clement M, Peeters D, Van Loock M, Koul A, Buyck C, Van Gool M, Van Damme E. Doijen J, et al. Among authors: van gool m. Antiviral Res. 2024 Feb;222:105789. doi: 10.1016/j.antiviral.2023.105789. Epub 2023 Dec 27. Antiviral Res. 2024. PMID: 38158129 Free article.
Identification of Z-Tyr-Ala-CHN2, a Cathepsin L Inhibitor with Broad-Spectrum Cell-Specific Activity against Coronaviruses, including SARS-CoV-2.
Doijen J, Temmerman K, Van den Eynde C, Diels A, Van den Broeck N, Van Gool M, Heo I, Jaensch S, Zwaagstra M, Diosa Toro M, Chiu W, De Jonghe S, Leyssen P, Bojkova D, Ciesek S, Cinatl J, Verschueren L, Buyck C, Van Kuppeveld F, Neyts J, Van Loock M, Van Damme E. Doijen J, et al. Among authors: van gool m. Microorganisms. 2023 Mar 10;11(3):717. doi: 10.3390/microorganisms11030717. Microorganisms. 2023. PMID: 36985290 Free PMC article.
49 results