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The pyruvate dehydrogenase kinase inhibitor dichloroacetate mitigates alcohol-induced hepatic inflammation and metabolic disturbances in mice.
Wu J, Huang E, McMullen MR, Singh V, Mrdjen M, Bellar A, Wang L, Welch N, Dasarathy J, Dasarathy S, Streem D, Brown JM, Nagy LE. Wu J, et al. Among authors: mrdjen m. Hepatol Commun. 2024 Nov 29;8(12):e0547. doi: 10.1097/HC9.0000000000000547. eCollection 2024 Dec 1. Hepatol Commun. 2024. PMID: 39621302 Free PMC article.
Gut microbial trimethylamine is elevated in alcohol-associated hepatitis and contributes to ethanol-induced liver injury in mice.
Helsley RN, Miyata T, Kadam A, Varadharajan V, Sangwan N, Huang EC, Banerjee R, Brown AL, Fung KK, Massey WJ, Neumann C, Orabi D, Osborn LJ, Schugar RC, McMullen MR, Bellar A, Poulsen KL, Kim A, Pathak V, Mrdjen M, Anderson JT, Willard B, McClain CJ, Mitchell M, McCullough AJ, Radaeva S, Barton B, Szabo G, Dasarathy S, Garcia-Garcia JC, Rotroff DM, Allende DS, Wang Z, Hazen SL, Nagy LE, Brown JM. Helsley RN, et al. Among authors: mrdjen m. Elife. 2022 Jan 27;11:e76554. doi: 10.7554/eLife.76554. Elife. 2022. PMID: 35084335 Free PMC article.
Metaorganismal choline metabolism shapes olfactory perception.
Massey WJ, Kay KE, Jaramillo TC, Horak AJ 3rd, Cao S, Osborn LJ, Banerjee R, Mrdjen M, Hamoudi MK, Silver DJ, Burrows AC, Brown AL, Reizes O, Lathia JD, Wang Z, Hazen SL, Brown JM. Massey WJ, et al. Among authors: mrdjen m. J Biol Chem. 2023 Nov;299(11):105299. doi: 10.1016/j.jbc.2023.105299. Epub 2023 Sep 28. J Biol Chem. 2023. PMID: 37777156 Free PMC article.
Circulating Gut Microbe-Derived Metabolites Are Associated with Hepatocellular Carcinoma.
Banerjee R, Wehrle CJ, Wang Z, Wilcox JD, Uppin V, Varadharajan V, Mrdjen M, Hershberger C, Reizes O, Yu JS, Lathia JD, Rotroff DM, Hazen SL, Tang WHW, Aucejo F, Brown JM. Banerjee R, et al. Among authors: mrdjen m. Biomedicines. 2024 Aug 26;12(9):1946. doi: 10.3390/biomedicines12091946. Biomedicines. 2024. PMID: 39335460 Free PMC article.
11 results