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Seeding-competent TDP-43 persists in human patient and mouse muscle.
Lynch EM, Pittman S, Daw J, Ikenaga C, Chen S, Dhavale DD, Jackrel ME, Ayala YM, Kotzbauer P, Ly CV, Pestronk A, Lloyd TE, Weihl CC. Lynch EM, et al. Among authors: jackrel me. Sci Transl Med. 2024 Nov 27;16(775):eadp5730. doi: 10.1126/scitranslmed.adp5730. Epub 2024 Nov 27. Sci Transl Med. 2024. PMID: 39602508
Seeding competent TDP-43 persists in human patient and mouse muscle.
Lynch EM, Pittman S, Daw J, Ikenaga C, Chen S, Dhavale DD, Jackrel ME, Ayala YM, Kotzbauer P, Ly CV, Pestronk A, Lloyd TE, Weihl CC. Lynch EM, et al. Among authors: jackrel me. bioRxiv [Preprint]. 2024 Apr 4:2024.04.03.587918. doi: 10.1101/2024.04.03.587918. bioRxiv. 2024. Update in: Sci Transl Med. 2024 Nov 27;16(775):eadp5730. doi: 10.1126/scitranslmed.adp5730 PMID: 38617354 Free PMC article. Updated. Preprint.
MANF stimulates autophagy and restores mitochondrial homeostasis to treat autosomal dominant tubulointerstitial kidney disease in mice.
Kim Y, Li C, Gu C, Fang Y, Tycksen E, Puri A, Pietka TA, Sivapackiam J, Kidd K, Park SJ, Johnson BG, Kmoch S, Duffield JS, Bleyer AJ, Jackrel ME, Urano F, Sharma V, Lindahl M, Chen YM. Kim Y, et al. Among authors: jackrel me. Nat Commun. 2023 Oct 14;14(1):6493. doi: 10.1038/s41467-023-42154-0. Nat Commun. 2023. PMID: 37838725 Free PMC article.
Tuning Hsp104 specificity to selectively detoxify α-synuclein.
Mack KL, Kim H, Barbieri EM, Lin J, Braganza S, Jackrel ME, DeNizio JE, Yan X, Chuang E, Tariq A, Cupo RR, Castellano LM, Caldwell KA, Caldwell GA, Shorter J. Mack KL, et al. Among authors: jackrel me. Mol Cell. 2023 Sep 21;83(18):3314-3332.e9. doi: 10.1016/j.molcel.2023.07.029. Epub 2023 Aug 24. Mol Cell. 2023. PMID: 37625404 Free PMC article.
MANF stimulates autophagy and restores mitochondrial homeostasis to treat toxic proteinopathy.
Kim Y, Li C, Gu C, Tycksen E, Puri A, Pietka TA, Sivapackiam J, Fang Y, Kidd K, Park SJ, Johnson BG, Kmoch S, Duffield JS, Bleyer AJ, Jackrel ME, Urano F, Sharma V, Lindahl M, Chen YM. Kim Y, et al. Among authors: jackrel me. bioRxiv [Preprint]. 2023 Jan 12:2023.01.10.523171. doi: 10.1101/2023.01.10.523171. bioRxiv. 2023. Update in: Nat Commun. 2023 Oct 14;14(1):6493. doi: 10.1038/s41467-023-42154-0 PMID: 36711449 Free PMC article. Updated. Preprint.
41 results