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The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo.
Vind AC, Wu Z, Firdaus MJ, Snieckute G, Toh GA, Jessen M, Martínez JF, Haahr P, Andersen TL, Blasius M, Koh LF, Maartensson NL, Common JEA, Gyrd-Hansen M, Zhong FL, Bekker-Jensen S. Vind AC, et al. Among authors: gyrd hansen m. Mol Cell. 2024 Nov 19:S1097-2765(24)00884-0. doi: 10.1016/j.molcel.2024.10.044. Online ahead of print. Mol Cell. 2024. PMID: 39591967
Advancements in pathogen immunity and signaling.
Gyrd-Hansen M, Kajaste-Rudnitski A, Manel N, Rehwinkel J, van der Veen AG, Iannacone M. Gyrd-Hansen M, et al. Nat Immunol. 2024 Aug;25(8):1322-1325. doi: 10.1038/s41590-024-01905-x. Nat Immunol. 2024. PMID: 39009840 No abstract available.
A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death.
Mannion J, Gifford V, Bellenie B, Fernando W, Ramos Garcia L, Wilson R, John SW, Udainiya S, Patin EC, Tiu C, Smith A, Goicoechea M, Craxton A, Moraes de Vasconcelos N, Guppy N, Cheung KJ, Cundy NJ, Pierrat O, Brennan A, Roumeliotis TI, Benstead-Hume G, Alexander J, Muirhead G, Layzell S, Lyu W, Roulstone V, Allen M, Baldock H, Legrand A, Gabel F, Serrano-Aparicio N, Starling C, Guo H, Upton J, Gyrd-Hansen M, MacFarlane M, Seddon B, Raynaud F, Roxanis I, Harrington K, Haider S, Choudhary JS, Hoelder S, Tenev T, Meier P. Mannion J, et al. Among authors: gyrd hansen m. Immunity. 2024 Jul 9;57(7):1514-1532.e15. doi: 10.1016/j.immuni.2024.04.025. Epub 2024 May 23. Immunity. 2024. PMID: 38788712 Free article.
Human ZBP1 induces cell death-independent inflammatory signaling via RIPK3 and RIPK1.
Peng R, Wang CK, Wang-Kan X, Idorn M, Kjaer M, Zhou FY, Fiil BK, Timmermann F, Orozco SL, McCarthy J, Leung CS, Lu X, Bagola K, Rehwinkel J, Oberst A, Maelfait J, Paludan SR, Gyrd-Hansen M. Peng R, et al. Among authors: gyrd hansen m. EMBO Rep. 2022 Dec 6;23(12):e55839. doi: 10.15252/embr.202255839. Epub 2022 Oct 21. EMBO Rep. 2022. PMID: 36268590 Free PMC article.
The Met1-linked ubiquitin machinery in inflammation and infection.
Fiil BK, Gyrd-Hansen M. Fiil BK, et al. Among authors: gyrd hansen m. Cell Death Differ. 2021 Feb;28(2):557-569. doi: 10.1038/s41418-020-00702-x. Epub 2021 Jan 20. Cell Death Differ. 2021. PMID: 33473179 Free PMC article. Review.
RIPK2 NODs to XIAP and IBD.
Topal Y, Gyrd-Hansen M. Topal Y, et al. Among authors: gyrd hansen m. Semin Cell Dev Biol. 2021 Jan;109:144-150. doi: 10.1016/j.semcdb.2020.07.001. Epub 2020 Jul 3. Semin Cell Dev Biol. 2021. PMID: 32631784 Review.
47 results