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Trametinib and M17, a novel small molecule inhibitor of AKT, display a synergistic antitumor effect in triple negative breast cancer cells through the AKT/mTOR and MEK/ERK pathways.
Han H, Yang M, Wen Z, Mei F, Chen Q, Ma Y, Lai X, Zhang Y, Fang R, Yin T, Sun S, Wang X, Qi J, Lin H, Yang Y. Han H, et al. Among authors: wang x. Bioorg Chem. 2024 Nov 22;154:107981. doi: 10.1016/j.bioorg.2024.107981. Online ahead of print. Bioorg Chem. 2024. PMID: 39591692
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