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Designed miniproteins potently inhibit and protect against MERS-CoV.
Ragotte RJ, Alejandra Tortorici M, Catanzaro NJ, Addetia A, Coventry B, Froggatt HM, Lee J, Stewart C, Brown JT, Goreshnik I, Sims JN, Milles LF, Wicky BIM, Glögl M, Gerben S, Kang A, Bera AK, Sharkey W, Schäfer A, Baric RS, Baker D, Veesler D. Ragotte RJ, et al. Among authors: catanzaro nj. bioRxiv [Preprint]. 2024 Nov 4:2024.11.03.621760. doi: 10.1101/2024.11.03.621760. bioRxiv. 2024. PMID: 39574666 Free PMC article. Preprint.
An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo.
Zhou NE, Tang S, Bian X, Parai MK, Krieger IV, Flores A, Jaiswal PK, Bam R, Wood JL, Shi Z, Stevens LJ, Scobey T, Diefenbacher MV, Moreira FR, Baric TJ, Acharya A, Shin J, Rathi MM, Wolff KC, Riva L, Bakowski MA, McNamara CW, Catanzaro NJ, Graham RL, Schultz DC, Cherry S, Kawaoka Y, Halfmann PJ, Baric RS, Denison MR, Sheahan TP, Sacchettini JC. Zhou NE, et al. Among authors: catanzaro nj. Cell Rep. 2024 Nov 5;43(11):114929. doi: 10.1016/j.celrep.2024.114929. Online ahead of print. Cell Rep. 2024. PMID: 39504242 Free article.
Computationally designed mRNA-launched protein nanoparticle vaccines.
Hendricks GG, Grigoryan L, Navarro MJ, Catanzaro NJ, Hubbard ML, Powers JM, Mattocks M, Treichel C, Walls AC, Lee J, Ellis D, Wang JYJ, Cheng S, Miranda MC, Valdez A, Chao CW, Chan S, Men C, Johnson MR, Hui H, Wu SY, Lujan V, Muramatsu H, Lin PJC, Sung MMH, Tam YK, Leaf EM, Pardi N, Baric RS, Pulendran B, Veesler D, Schäfer A, King NP. Hendricks GG, et al. Among authors: catanzaro nj. bioRxiv [Preprint]. 2024 Jul 23:2024.07.22.604655. doi: 10.1101/2024.07.22.604655. bioRxiv. 2024. PMID: 39091730 Free PMC article. Preprint.
The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses.
Martinez DR, Moreira FR, Catanzaro NJ, Diefenbacher MV, Zweigart MR, Gully KL, De la Cruz G, Brown AJ, Adams LE, Yount B, Baric TJ, Mallory ML, Conrad H, May SR, Dong S, Scobey DT, Nguyen C, Montgomery SA, Perry JK, Babusis D, Barrett KT, Nguyen AH, Nguyen AQ, Kalla R, Bannister R, Feng JY, Cihlar T, Baric RS, Mackman RL, Bilello JP, Schäfer A, Sheahan TP. Martinez DR, et al. Among authors: catanzaro nj. Sci Transl Med. 2024 May 22;16(748):eadj4504. doi: 10.1126/scitranslmed.adj4504. Epub 2024 May 22. Sci Transl Med. 2024. PMID: 38776389 Free PMC article.
Mapping of susceptibility loci for Ebola virus pathogenesis in mice.
Schäfer A, Marzi A, Furuyama W, Catanzaro NJ, Nguyen C, Haddock E, Feldmann F, Meade-White K, Thomas T, Hubbard ML, Gully KL, Leist SR, Hock P, Bell TA, De la Cruz GE, Midkiff BR, Martinez DR, Shaw GD, Miller DR, Vernon MJ, Graham RL, Cowley DO, Montgomery SA, Schughart K, de Villena FPM, Wilkerson GK, Ferris MT, Feldmann H, Baric RS. Schäfer A, et al. Among authors: catanzaro nj. Cell Rep. 2024 May 28;43(5):114127. doi: 10.1016/j.celrep.2024.114127. Epub 2024 Apr 21. Cell Rep. 2024. PMID: 38652660 Free PMC article.
mRNA-LNP vaccine-induced CD8+ T cells protect mice from lethal SARS-CoV-2 infection in the absence of specific antibodies.
Montoya B, Melo-Silva CR, Tang L, Kafle S, Lidskiy P, Bajusz C, Vadovics M, Muramatsu H, Abraham E, Lipinszki Z, Chatterjee D, Scher G, Benitez J, Sung MMH, Tam YK, Catanzaro NJ, Schäfer A, Andino R, Baric RS, Martinez DR, Pardi N, Sigal LJ. Montoya B, et al. Among authors: catanzaro nj. Mol Ther. 2024 Jun 5;32(6):1790-1804. doi: 10.1016/j.ymthe.2024.04.019. Epub 2024 Apr 11. Mol Ther. 2024. PMID: 38605519 Free article.
Protein nanoparticle vaccines induce potent neutralizing antibody responses against MERS-CoV.
Chao CW, Sprouse KR, Miranda MC, Catanzaro NJ, Hubbard ML, Addetia A, Stewart C, Brown JT, Dosey A, Valdez A, Ravichandran R, Hendricks GG, Ahlrichs M, Dobbins C, Hand A, Treichel C, Willoughby I, Walls AC, McGuire AT, Leaf EM, Baric RS, Schäfer A, Veesler D, King NP. Chao CW, et al. Among authors: catanzaro nj. bioRxiv [Preprint]. 2024 Mar 14:2024.03.13.584735. doi: 10.1101/2024.03.13.584735. bioRxiv. 2024. PMID: 38558973 Free PMC article. Preprint.
Engineered immunogens to elicit antibodies against conserved coronavirus epitopes.
Kapingidza AB, Marston DJ, Harris C, Wrapp D, Winters K, Mielke D, Xiaozhi L, Yin Q, Foulger A, Parks R, Barr M, Newman A, Schäfer A, Eaton A, Flores JM, Harner A, Catanzaro NJ Jr, Mallory ML, Mattocks MD, Beverly C, Rhodes B, Mansouri K, Van Itallie E, Vure P, Dunn B, Keyes T, Stanfield-Oakley S, Woods CW, Petzold EA, Walter EB, Wiehe K, Edwards RJ, Montefiori DC, Ferrari G, Baric R, Cain DW, Saunders KO, Haynes BF, Azoitei ML. Kapingidza AB, et al. Among authors: catanzaro nj jr. Nat Commun. 2023 Nov 30;14(1):7897. doi: 10.1038/s41467-023-43638-9. Nat Commun. 2023. PMID: 38036525 Free PMC article.
17 results