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Oncogenic Enhancers in Leukemia.
Mulet-Lazaro R, Delwel R. Mulet-Lazaro R, et al. Among authors: delwel r. Blood Cancer Discov. 2024 Sep 3;5(5):303-317. doi: 10.1158/2643-3230.BCD-23-0211. Blood Cancer Discov. 2024. PMID: 39093124 Review.
STAG2 mutations reshape the cohesin-structured spatial chromatin architecture to drive gene regulation in acute myeloid leukemia.
Fischer A, Hernández-Rodríguez B, Mulet-Lazaro R, Nuetzel M, Hölzl F, van Herk S, Kavelaars FG, Stanewsky H, Ackermann U, Niang AH, Diaz N, Reuschel E, Strieder N, Hernández-López I, Valk PJM, Vaquerizas JM, Rehli M, Delwel R, Gebhard C. Fischer A, et al. Among authors: delwel r. Cell Rep. 2024 Aug 27;43(8):114498. doi: 10.1016/j.celrep.2024.114498. Epub 2024 Jul 30. Cell Rep. 2024. PMID: 39084219 Free article.
Epigenetic alterations affecting hematopoietic regulatory networks as drivers of mixed myeloid/lymphoid leukemia.
Mulet-Lazaro R, van Herk S, Nuetzel M, Sijs-Szabo A, Díaz N, Kelly K, Erpelinck-Verschueren C, Schwarzfischer-Pfeilschifter L, Stanewsky H, Ackermann U, Glatz D, Raithel J, Fischer A, Pohl S, Rijneveld A, Vaquerizas JM, Thiede C, Plass C, Wouters BJ, Delwel R, Rehli M, Gebhard C. Mulet-Lazaro R, et al. Among authors: delwel r. Nat Commun. 2024 Jul 7;15(1):5693. doi: 10.1038/s41467-024-49811-y. Nat Commun. 2024. PMID: 38972954 Free PMC article.
Oncogene EVI1 drives acute myeloid leukemia via a targetable interaction with CTBP2.
Pastoors D, Havermans M, Mulet-Lazaro R, Brian D, Noort W, Grasel J, Hoogenboezem R, Smeenk L, Demmers JAA, Milsom MD, Enver T, Groen RWJ, Bindels E, Delwel R. Pastoors D, et al. Among authors: delwel r. Sci Adv. 2024 May 17;10(20):eadk9076. doi: 10.1126/sciadv.adk9076. Epub 2024 May 15. Sci Adv. 2024. PMID: 38748792 Free PMC article.
Cellular and metabolic characteristics of pre-leukemic hematopoietic progenitors with GATA2 haploinsufficiency.
Rein A, Geron I, Kugler E, Fishman H, Gottlieb E, Abramovich I, Giladi A, Amit I, Mulet-Lazaro R, Delwel R, Gröschel S, Levin-Zaidman S, Dezorella N, Holdengreber V, Rao TN, Yacobovich J, Steinberg-Shemer O, Huang QH, Tan Y, Chen SJ, Izraeli S, Birger Y. Rein A, et al. Among authors: delwel r. Haematologica. 2023 Sep 1;108(9):2316-2330. doi: 10.3324/haematol.2022.279437. Haematologica. 2023. PMID: 36475518 Free PMC article.
EVI1 drives leukemogenesis through aberrant ERG activation.
Schmoellerl J, Barbosa IAM, Minnich M, Andersch F, Smeenk L, Havermans M, Eder T, Neumann T, Jude J, Fellner M, Ebert A, Steininger M, Delwel R, Grebien F, Zuber J. Schmoellerl J, et al. Among authors: delwel r. Blood. 2023 Feb 2;141(5):453-466. doi: 10.1182/blood.2022016592. Blood. 2023. PMID: 36095844 Free article.
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