Schittenhelm RB - Search Results

1

Structure of the human TSC:WIPI3 lysosomal recruitment complex.

Bayly-Jones C, Lupton CJ, D'Andrea L, Chang YG, Jones GD, Steele JR, Venugopal H, Schittenhelm RB, Halls ML, Ellisdon AM. Bayly-Jones C, et al. Among authors: schittenhelm rb. Sci Adv. 2024 Nov 22;10(47):eadr5807. doi: 10.1126/sciadv.adr5807. Epub 2024 Nov 20. Sci Adv. 2024. PMID: 39565846 Free PMC article.

2

The cryo-EM structure of the human neurofibromin dimer reveals the molecular basis for neurofibromatosis type 1.

Lupton CJ, Bayly-Jones C, D'Andrea L, Huang C, Schittenhelm RB, Venugopal H, Whisstock JC, Halls ML, Ellisdon AM. Lupton CJ, et al. Among authors: schittenhelm rb. Nat Struct Mol Biol. 2021 Dec;28(12):982-988. doi: 10.1038/s41594-021-00687-2. Epub 2021 Dec 9. Nat Struct Mol Biol. 2021. PMID: 34887559

3

Structural analysis of the PTEN:P-Rex2 signaling complex reveals how cancer-associated mutations coordinate to hyperactivate Rac1.

D'Andrea L, Lucato CM, Marquez EA, Chang YG, Civciristov S, Mastos C, Lupton CJ, Huang C, Elmlund H, Schittenhelm RB, Mitchell CA, Whisstock JC, Halls ML, Ellisdon AM. D'Andrea L, et al. Among authors: schittenhelm rb. Sci Signal. 2021 May 4;14(681):eabc4078. doi: 10.1126/scisignal.abc4078. Sci Signal. 2021. PMID: 33947796

4

Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism.

Chang YG, Lupton CJ, Bayly-Jones C, Keen AC, D'Andrea L, Lucato CM, Steele JR, Venugopal H, Schittenhelm RB, Whisstock JC, Halls ML, Ellisdon AM. Chang YG, et al. Among authors: schittenhelm rb. Nat Struct Mol Biol. 2022 Aug;29(8):767-773. doi: 10.1038/s41594-022-00804-9. Epub 2022 Jul 21. Nat Struct Mol Biol. 2022. PMID: 35864164 Free PMC article.

5

Ligand-dependent spatiotemporal signaling profiles of the μ-opioid receptor are controlled by distinct protein-interaction networks.

Civciristov S, Huang C, Liu B, Marquez EA, Gondin AB, Schittenhelm RB, Ellisdon AM, Canals M, Halls ML. Civciristov S, et al. Among authors: schittenhelm rb. J Biol Chem. 2019 Nov 1;294(44):16198-16213. doi: 10.1074/jbc.RA119.008685. Epub 2019 Sep 12. J Biol Chem. 2019. PMID: 31515267 Free PMC article.

6

SAGA and SAGA-like SLIK transcriptional coactivators are structurally and biochemically equivalent.

Adamus K, Reboul C, Voss J, Huang C, Schittenhelm RB, Le SN, Ellisdon AM, Elmlund H, Boudes M, Elmlund D. Adamus K, et al. Among authors: schittenhelm rb. J Biol Chem. 2021 Jan-Jun;296:100671. doi: 10.1016/j.jbc.2021.100671. Epub 2021 Apr 15. J Biol Chem. 2021. PMID: 33864814 Free PMC article.

7

Sex-Dependent Changes to the Intestinal and Hepatic Abundance of Drug Transporters and Metabolizing Enzymes in the SOD1^G93A Mouse Model of Amyotrophic Lateral Sclerosis.

Koehn LM, Steele JR, Schittenhelm RB, Turner BJ, Nicolazzo JA. Koehn LM, et al. Among authors: schittenhelm rb. Mol Pharm. 2024 Apr 1;21(4):1756-1767. doi: 10.1021/acs.molpharmaceut.3c01089. Epub 2024 Feb 28. Mol Pharm. 2024. PMID: 38415587

8

INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer.

Rodgers SJ, Ooms LM, Oorschot VMJ, Schittenhelm RB, Nguyen EV, Hamila SA, Rynkiewicz N, Gurung R, Eramo MJ, Sriratana A, Fedele CG, Caramia F, Loi S, Kerr G, Abud HE, Ramm G, Papa A, Ellisdon AM, Daly RJ, McLean CA, Mitchell CA. Rodgers SJ, et al. Among authors: schittenhelm rb. Nat Commun. 2021 May 25;12(1):3140. doi: 10.1038/s41467-021-23241-6. Nat Commun. 2021. PMID: 34035258 Free PMC article.

9

Phospho-Analyst: An Interactive, Easy-to-Use Web Platform To Analyze Quantitative Phosphoproteomics Data.

Zhang H, Steele JR, Kahrood HV, Lucas DD, Shah AD, Schittenhelm RB. Zhang H, et al. Among authors: schittenhelm rb. J Proteome Res. 2023 Sep 1;22(9):2890-2899. doi: 10.1021/acs.jproteome.3c00186. Epub 2023 Aug 16. J Proteome Res. 2023. PMID: 37584946

10

A new isolation method for bacterial extracellular vesicles providing greater purity and improved proteomic detection of vesicle proteins.

Le LHM, Steele JR, Ying L, Schittenhelm RB, Ferrero RL. Le LHM, et al. Among authors: schittenhelm rb. J Extracell Biol. 2023 Apr 25;2(5):e84. doi: 10.1002/jex2.84. eCollection 2023 May. J Extracell Biol. 2023. PMID: 38938280 Free PMC article.

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