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De novo missense variants in the PP2A regulatory subunit PPP2R2B in a neurodevelopmental syndrome: potential links to mitochondrial dynamics and spinocerebellar ataxias.
Sandal P, Jong CJ, Merrill RA, Kollman GJ, Paden AH, Bend EG, Sullivan J, Spillmann RC, Shashi V, Vulto-van Silfhout AT, Pfundt R, de Vries BBA, Li PP, Bicknell LS, Strack S. Sandal P, et al. Among authors: merrill ra. Hum Mol Genet. 2024 Nov 20:ddae166. doi: 10.1093/hmg/ddae166. Online ahead of print. Hum Mol Genet. 2024. PMID: 39565297
The mitochondrial dicarboxylate carrier mediates in vivo hepatic gluconeogenesis.
Pape DJ, Falls-Hubert KC, Merrill RA, Ahmed A, Qian Q, McGivney GR, Sobieralski P, Rauckhorst AJ, Yang L, Taylor EB. Pape DJ, et al. Among authors: merrill ra. bioRxiv [Preprint]. 2024 Sep 13:2024.09.12.612761. doi: 10.1101/2024.09.12.612761. bioRxiv. 2024. PMID: 39314408 Free PMC article. Preprint.
B56δ long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan's syndrome mutations.
Wu CG, Balakrishnan VK, Merrill RA, Parihar PS, Konovolov K, Chen YC, Xu Z, Wei H, Sundaresan R, Cui Q, Wadzinski BE, Swingle MR, Musiyenko A, Chung WK, Honkanen RE, Suzuki A, Huang X, Strack S, Xing Y. Wu CG, et al. Among authors: merrill ra. Proc Natl Acad Sci U S A. 2024 Jan 2;121(1):e2310727120. doi: 10.1073/pnas.2310727120. Epub 2023 Dec 27. Proc Natl Acad Sci U S A. 2024. PMID: 38150499 Free PMC article.
Extended regulation interface coupled to the allosteric network and disease mutations in the PP2A-B56δ holoenzyme.
Wu CG, Balakrishnan VK, Parihar PS, Konovolov K, Chen YC, Merrill RA, Wei H, Carragher B, Sundaresan R, Cui Q, Wadzinski BE, Swingle MR, Musiyenko A, Honkanen R, Chung WK, Suzuki A, Strack S, Huang X, Xing Y. Wu CG, et al. Among authors: merrill ra. bioRxiv [Preprint]. 2023 Apr 5:2023.03.09.530109. doi: 10.1101/2023.03.09.530109. bioRxiv. 2023. PMID: 37066309 Free PMC article. Preprint.
The mitochondrial pyruvate carrier complex potentiates the efficacy of proteasome inhibitors in multiple myeloma.
Findlay S, Nair R, Merrill RA, Kaiser Z, Cajelot A, Aryanpour Z, Heath J, St-Louis C, Papadopoli D, Topisirovic I, St-Pierre J, Sebag M, Kesarwala AH, Hulea L, Taylor EB, Shanmugam M, Orthwein A. Findlay S, et al. Among authors: merrill ra. Blood Adv. 2023 Jul 25;7(14):3485-3500. doi: 10.1182/bloodadvances.2022008345. Blood Adv. 2023. PMID: 36920785 Free PMC article.
The BBSome regulates mitochondria dynamics and function.
Guo DF, Merrill RA, Qian L, Hsu Y, Zhang Q, Lin Z, Thedens DR, Usachev YM, Grumbach I, Sheffield VC, Strack S, Rahmouni K. Guo DF, et al. Among authors: merrill ra. Mol Metab. 2023 Jan;67:101654. doi: 10.1016/j.molmet.2022.101654. Epub 2022 Dec 10. Mol Metab. 2023. PMID: 36513220 Free PMC article.
45 results