Lefer DJ - Search Results

1

A Bifunctional Sulfide Donor Approach for Ischemic Stroke: Leveraging Butylphthalide as a Carrier for Sulfide Prodrug.

Peng W, Liu J, Li Z, Wang Y, Sun Y, Chen Y, Lefer DJ, Guo W, Zheng Y. Peng W, et al. Among authors: lefer dj. J Med Chem. 2024 Nov 28;67(22):20695-20707. doi: 10.1021/acs.jmedchem.4c02454. Epub 2024 Nov 20. J Med Chem. 2024. PMID: 39565094

2

Integrated systems biology identifies disruptions in mitochondrial function and metabolism as key contributors to heart failure with preserved ejection fraction (HFpEF).

Gibb AA, LaPenna K, Gaspar RB, Latchman NR, Tan Y, Choya-Foces C, Doiron JE, Li Z, Xia H, Lazaropoulos MP, Conwell M, Sharp TE 3rd, Goodchild TT, Lefer DJ, Elrod JW. Gibb AA, et al. Among authors: lefer dj. bioRxiv [Preprint]. 2024 Oct 25:2024.10.25.619450. doi: 10.1101/2024.10.25.619450. bioRxiv. 2024. PMID: 39484400 Free PMC article. Preprint.

3

Nitric oxide donors rescue metabolic and mitochondrial dysfunction in obese Alzheimer's model.

Allerton TD, Stampley JE, Li Z, Yu X, Quiariate H, Doiron JE, White G, Wigger Z, Gartia MR, Lefer DJ, Soto P, Irving BA. Allerton TD, et al. Among authors: lefer dj. Sci Rep. 2024 Oct 30;14(1):26118. doi: 10.1038/s41598-024-75870-8. Sci Rep. 2024. PMID: 39478095 Free PMC article.

4

Rapid onset fibrotic remodeling and ventricular dysfunction induced by phenylephrine involve targeted reprogramming of myocyte and fibroblast transcriptomes.

Kimball TH, Gromova T, Gehred ND, Chapski DJ, Wang K, Vaseghi M, Fischer MA, Lefer DJ, Vondriska TM. Kimball TH, et al. Among authors: lefer dj. bioRxiv [Preprint]. 2024 Oct 15:2024.10.11.617933. doi: 10.1101/2024.10.11.617933. bioRxiv. 2024. PMID: 39464022 Free PMC article. Preprint.

5

"Circulating Inflammation" and the Plasma Proteome in Heart Failure With Preserved Ejection Fraction.

Vondriska TM, Lefer DJ. Vondriska TM, et al. Among authors: lefer dj. JACC Basic Transl Sci. 2024 Sep 23;9(9):1085-1087. doi: 10.1016/j.jacbts.2024.07.004. eCollection 2024 Sep. JACC Basic Transl Sci. 2024. PMID: 39444925 Free PMC article.

6

Cardiomyocyte myofilament function in common animal models of heart failure with preserved ejection fraction.

Jani VP, Koleini N, Fenwick AJ, Sharp TE, Goodchild TT, Hill JA, Lefer DJ, Cammarato A, Kass DA. Jani VP, et al. Among authors: lefer dj. J Mol Cell Cardiol. 2024 Dec;197:34-39. doi: 10.1016/j.yjmcc.2024.10.005. Epub 2024 Oct 18. J Mol Cell Cardiol. 2024. PMID: 39427968

7

Reduced Hydrogen Sulfide Bioavailability Contributes to Cardiometabolic Heart Failure with Preserved Ejection Fraction.

Doiron JE, Elbatreek MH, Xia H, Yu X, Wilson Tang WH, LaPenna KB, Sharp TE, Goodchild TT, Xian M, Xu S, Quiriarte H, Allerton TD, Zagouras A, Wilcox J, Shah SJ, Pfeilschifter J, Beck KF, Li Z, Lefer DJ. Doiron JE, et al. Among authors: lefer dj. bioRxiv [Preprint]. 2024 Sep 19:2024.09.16.613349. doi: 10.1101/2024.09.16.613349. bioRxiv. 2024. PMID: 39345440 Free PMC article. Preprint.

8

A Highly Atom-Efficient Prodrug Approach to Generate Synergy between H₂S and Nonsteroidal Anti-inflammatory Drugs and Improve Safety.

Peng W, Qin L, Wang T, Sun Y, Li Z, Lefer DJ, Luo C, Ye F, Wang B, Guo W, Zheng Y. Peng W, et al. Among authors: lefer dj. J Med Chem. 2024 Oct 10;67(19):17350-17362. doi: 10.1021/acs.jmedchem.4c01254. Epub 2024 Sep 24. J Med Chem. 2024. PMID: 39316761

9

Adjunctive therapy with an oral H₂S donor provides additional therapeutic benefit beyond SGLT2 inhibition in cardiometabolic heart failure with preserved ejection fraction.

Doiron JE, Xia H, Yu X, Nevins AR, LaPenna KB, Sharp TE 3rd, Goodchild TT, Allerton TD, Elgazzaz M, Lazartigues E, Shah SJ, Li Z, Lefer DJ. Doiron JE, et al. Among authors: lefer dj. Br J Pharmacol. 2024 Nov;181(21):4294-4310. doi: 10.1111/bph.16493. Epub 2024 Jul 9. Br J Pharmacol. 2024. PMID: 38982742

10

Early Renal Denervation Attenuates Cardiac Dysfunction in Heart Failure With Preserved Ejection Fraction.

Doiron JE, Li Z, Yu X, LaPenna KB, Quiriarte H, Allerton TD, Koul K, Malek A, Shah SJ, Sharp TE, Goodchild TT, Kapusta DR, Lefer DJ. Doiron JE, et al. Among authors: lefer dj. J Am Heart Assoc. 2024 Feb 20;13(4):e032646. doi: 10.1161/JAHA.123.032646. Epub 2024 Feb 14. J Am Heart Assoc. 2024. PMID: 38353216 Free PMC article.

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