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Tumor cell-derived spermidine promotes a pro-tumorigenic immune microenvironment in glioblastoma via CD8+ T cell inhibition.
Kay KE, Lee J, Hong ES, Beilis J, Dayal S, Wesley ER, Mitchell S, Wang SZ, Silver DJ, Volovetz J, Johnson S, McGraw M, Grabowski M, Lu T, Freytag L, Narayana VK, Freytag S, Best SA, Whittle JR, Wang Z, Reizes O, Yu JS, Hazen SL, Brown JM, Bayik D, Lathia J. Kay KE, et al. Among authors: bayik d. J Clin Invest. 2024 Nov 19:e177824. doi: 10.1172/JCI177824. Online ahead of print. J Clin Invest. 2024. PMID: 39561012 Free article.
Targeting ZNF638 activates antiviral immune responses and potentiates immune checkpoint inhibition in glioblastoma.
Seetharam D, Chandar J, Ramsoomair CK, Desgraves JF, Medina AA, Hudson AJ, Amidei A, Castro JR, Govindarajan V, Wang S, Zhang Y, Sonabend AM, Valdez MJM, Maric D, Govindarajan V, Rivas SR, Lu VM, Tiwari R, Sharifi N, Thomas E, Alexander M, DeMarino C, Johnson K, De La Fuente MI, Nasany RA, Noviello TMR, Ivan ME, Komotar RJ, Iavarone A, Nath A, Heiss J, Ceccarelli M, Chiappinelli KB, Figueroa ME, Bayik D, Shah AH. Seetharam D, et al. Among authors: bayik d. bioRxiv [Preprint]. 2024 Oct 15:2024.10.13.618076. doi: 10.1101/2024.10.13.618076. bioRxiv. 2024. PMID: 39464150 Free PMC article. Preprint.
γ-aminobutyric acid receptor B signaling drives glioblastoma in females in an immune-dependent manner.
Pathak A, Palasalava S, Knott MV, Colon B, Ciervo E, Zhou Y, Mitchell J, Pumar OT, Wong HKA, Zhang L, Susic N, Shah KH, Kay K, Chin D, Johnson S, Cheng F, Lyssiotis CA, Watson DC, Ceccarelli M, Shah A, Wahl DR, Lathia JD, Bayik D. Pathak A, et al. Among authors: bayik d. bioRxiv [Preprint]. 2024 Jul 22:2024.07.18.603996. doi: 10.1101/2024.07.18.603996. bioRxiv. 2024. PMID: 39091833 Free PMC article. Preprint.
Tumor cell-derived spermidine promotes a pro-tumorigenic immune microenvironment in glioblastoma via CD8+ T cell inhibition.
Kay KE, Lee J, Hong ES, Beilis J, Dayal S, Wesley E, Mitchell S, Wang SZ, Silver DJ, Volovetz J, Johnson S, McGraw M, Grabowski MM, Lu T, Freytag L, Narayana V, Freytag S, Best SA, Whittle JR, Wang Z, Reizes O, Yu JS, Hazen SL, Brown JM, Bayik D, Lathia JD. Kay KE, et al. Among authors: bayik d. bioRxiv [Preprint]. 2023 Nov 16:2023.11.14.567048. doi: 10.1101/2023.11.14.567048. bioRxiv. 2023. PMID: 38014234 Free PMC article. Preprint.
'Slicing' glioblastoma drivers with the Swiss cheese model.
Teran Pumar OY, Lathia JD, Watson DC, Bayik D. Teran Pumar OY, et al. Among authors: bayik d. Trends Cancer. 2024 Jan;10(1):15-27. doi: 10.1016/j.trecan.2023.08.002. Epub 2023 Aug 23. Trends Cancer. 2024. PMID: 37625928 Free article. Review.
Sex-Biased T-cell Exhaustion Drives Differential Immune Responses in Glioblastoma.
Lee J, Nicosia M, Hong ES, Silver DJ, Li C, Bayik D, Watson DC, Lauko A, Kay KE, Wang SZ, Johnson S, McGraw M, Grabowski MM, Kish DD, Desai AB, Goodman WA, Cameron SJ, Okada H, Valujskikh A, Fairchild RL, Ahluwalia MS, Lathia JD. Lee J, et al. Among authors: bayik d. Cancer Discov. 2023 Sep 6;13(9):2090-2105. doi: 10.1158/2159-8290.CD-22-0869. Cancer Discov. 2023. PMID: 37378557 Free PMC article.
The MIF promoter SNP rs755622 is associated with immune activation in glioblastoma.
Alban TJ, Grabowski MM, Otvos B, Bayik D, Wang W, Zalavadia A, Makarov V, Troike K, McGraw M, Rabljenovic A, Lauko A, Neumann C, Roversi G, Waite KA, Cioffi G, Patil N, Tran TT, McCortney K, Steffens A, Diaz CM, Brown JM, Egan KM, Horbinski CM, Barnholtz-Sloan JS, Rajappa P, Vogelbaum MA, Bucala R, Chan TA, Ahluwalia MS, Lathia JD. Alban TJ, et al. Among authors: bayik d. JCI Insight. 2023 Jul 10;8(13):e160024. doi: 10.1172/jci.insight.160024. JCI Insight. 2023. PMID: 37252795 Free PMC article.
44 results