Roche SP - Search Results

1

A platform of ADAPTive scaffolds: development of CDR-H3 β-hairpin mimics into covalent inhibitors of the PD1/PDL1 immune checkpoint.

Naylon SH, Richaud AD, Zhao G, Bui L, Dufresne CP, Wu CJ, Wangpaichitr M, Savaraj N, Roche SP. Naylon SH, et al. Among authors: roche sp. RSC Chem Biol. 2024 Nov 4;5(12):1259-70. doi: 10.1039/d4cb00174e. Online ahead of print. RSC Chem Biol. 2024. PMID: 39552936 Free PMC article.

2

Exploiting the Innate Plasticity of the Programmed Cell Death-1 (PD1) Receptor to Design Pembrolizumab H3 Loop Mimics.

Richaud AD, Zaghouani M, Zhao G, Wangpaichitr M, Savaraj N, Roche SP. Richaud AD, et al. Among authors: roche sp. Chembiochem. 2022 Nov 4;23(21):e202200449. doi: 10.1002/cbic.202200449. Epub 2022 Sep 27. Chembiochem. 2022. PMID: 36082509 Free PMC article.

3

De Novo Synthesis and Structural Elucidation of CDR-H3 Loop Mimics.

Zhao G, Richaud AD, Williamson RT, Feig M, Roche SP. Zhao G, et al. Among authors: roche sp. ACS Chem Biol. 2024 Jul 19;19(7):1583-1592. doi: 10.1021/acschembio.4c00236. Epub 2024 Jun 25. ACS Chem Biol. 2024. PMID: 38916527

4

Structure-Property Relationship Study of N-(Hydroxy)Peptides for the Design of Self-Assembled Parallel β-Sheets.

Richaud AD, Roche SP. Richaud AD, et al. Among authors: roche sp. J Org Chem. 2020 Oct 2;85(19):12329-12342. doi: 10.1021/acs.joc.0c01441. Epub 2020 Sep 17. J Org Chem. 2020. PMID: 32881524 Free PMC article.

5

Folding in Place: Design of β-Strap Motifs to Stabilize the Folding of Hairpins with Long Loops.

Richaud AD, Zhao G, Hobloss S, Roche SP. Richaud AD, et al. Among authors: roche sp. J Org Chem. 2021 Oct 1;86(19):13535-13547. doi: 10.1021/acs.joc.1c01442. Epub 2021 Sep 9. J Org Chem. 2021. PMID: 34499510 Free PMC article.

6

Passive Membrane Permeability of Sizable Acyclic β-Hairpin Peptides.

Moxam J, Naylon S, Richaud AD, Zhao G, Padilla A, Roche SP. Moxam J, et al. Among authors: roche sp. ACS Med Chem Lett. 2023 Jan 27;14(3):278-284. doi: 10.1021/acsmedchemlett.2c00486. eCollection 2023 Mar 9. ACS Med Chem Lett. 2023. PMID: 36923919 Free PMC article.

7

Tunable CH/π Interactions within a Tryptophan Zipper Motif to Stabilize the Fold of Long β-Hairpin Peptides.

Richaud AD, Mandal S, Das A, Roche SP. Richaud AD, et al. Among authors: roche sp. ACS Chem Biol. 2023 Dec 15;18(12):2555-2563. doi: 10.1021/acschembio.3c00553. Epub 2023 Nov 17. ACS Chem Biol. 2023. PMID: 37976523

8

A Kinetic Dearomatization Strategy for an Expedient Biomimetic Route to the Bielschowskysin Skeleton.

Scesa P, Wangpaichitr M, Savaraj N, West L, Roche SP. Scesa P, et al. Among authors: roche sp. Angew Chem Int Ed Engl. 2018 Jan 26;57(5):1316-1321. doi: 10.1002/anie.201711780. Epub 2018 Jan 5. Angew Chem Int Ed Engl. 2018. PMID: 29232501

9

Intercepted-Knoevenagel condensation for the synthesis of unsymmetrical fused-tricyclic 4H-pyrans.

Shearer C, Desaunay O, Zorc S, Richaud AD, Samanta SS, Jeedimalla N, Roche SP. Shearer C, et al. Among authors: roche sp. Tetrahedron. 2019 Oct 25;75(43):130606. doi: 10.1016/j.tet.2019.130606. Epub 2019 Sep 17. Tetrahedron. 2019. PMID: 31741543 Free PMC article.

10

A Broad Substrate Scope of Aza-Friedel-Crafts Alkylation for the Synthesis of Quaternary α-Amino Esters.

Zhao G, Samanta SS, Michieletto J, Roche SP. Zhao G, et al. Among authors: roche sp. Org Lett. 2020 Aug 7;22(15):5822-5827. doi: 10.1021/acs.orglett.0c01895. Epub 2020 Jul 10. Org Lett. 2020. PMID: 32649206 Free PMC article.

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