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Page 1
Discovery of Molecular Glue Degraders via Isogenic Morphological Profiling.
Ng A, Offensperger F, Cisneros JA, Scholes NS, Malik M, Villanti L, Rukavina A, Ferrada E, Hannich JT, Koren A, Kubicek S, Superti-Furga G, Winter GE. Ng A, et al. Among authors: winter ge. ACS Chem Biol. 2023 Dec 15;18(12):2464-2473. doi: 10.1021/acschembio.3c00598. Epub 2023 Nov 21. ACS Chem Biol. 2023. PMID: 38098458 Free PMC article.
POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells.
Schrempf A, Bernardo S, Arasa Verge EA, Ramirez Otero MA, Wilson J, Kirchhofer D, Timelthaler G, Ambros AM, Kaya A, Wieder M, Ecker GF, Winter GE, Costanzo V, Loizou JI. Schrempf A, et al. Among authors: winter ge. Cell Rep. 2022 Nov 29;41(9):111716. doi: 10.1016/j.celrep.2022.111716. Epub 2022 Nov 17. Cell Rep. 2022. PMID: 36400033 Free article.
Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation.
Kagiou C, Cisneros JA, Farnung J, Liwocha J, Offensperger F, Dong K, Yang K, Tin G, Horstmann CS, Hinterndorfer M, Paulo JA, Scholes NS, Sanchez Avila J, Fellner M, Andersch F, Hannich JT, Zuber J, Kubicek S, Gygi SP, Schulman BA, Winter GE. Kagiou C, et al. Among authors: winter ge. Nat Commun. 2024 Jun 26;15(1):5409. doi: 10.1038/s41467-024-49739-3. Nat Commun. 2024. PMID: 38926334 Free PMC article.
Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML.
Brand M, Jiang B, Bauer S, Donovan KA, Liang Y, Wang ES, Nowak RP, Yuan JC, Zhang T, Kwiatkowski N, Müller AC, Fischer ES, Gray NS, Winter GE. Brand M, et al. Among authors: winter ge. Cell Chem Biol. 2019 Feb 21;26(2):300-306.e9. doi: 10.1016/j.chembiol.2018.11.006. Epub 2018 Dec 27. Cell Chem Biol. 2019. PMID: 30595531 Free PMC article.
Rational discovery of molecular glue degraders via scalable chemical profiling.
Mayor-Ruiz C, Bauer S, Brand M, Kozicka Z, Siklos M, Imrichova H, Kaltheuner IH, Hahn E, Seiler K, Koren A, Petzold G, Fellner M, Bock C, Müller AC, Zuber J, Geyer M, Thomä NH, Kubicek S, Winter GE. Mayor-Ruiz C, et al. Among authors: winter ge. Nat Chem Biol. 2020 Nov;16(11):1199-1207. doi: 10.1038/s41589-020-0594-x. Epub 2020 Aug 3. Nat Chem Biol. 2020. PMID: 32747809 Free PMC article.
Design principles for cyclin K molecular glue degraders.
Kozicka Z, Suchyta DJ, Focht V, Kempf G, Petzold G, Jentzsch M, Zou C, Di Genua C, Donovan KA, Coomar S, Cigler M, Mayor-Ruiz C, Schmid-Burgk JL, Häussinger D, Winter GE, Fischer ES, Słabicki M, Gillingham D, Ebert BL, Thomä NH. Kozicka Z, et al. Among authors: winter ge. Nat Chem Biol. 2024 Jan;20(1):93-102. doi: 10.1038/s41589-023-01409-z. Epub 2023 Sep 7. Nat Chem Biol. 2024. PMID: 37679459 Free PMC article.
68 results