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Page 1
In vivo models of subclonal oncogenesis and dependency in hematopoietic malignancy.
Bowman RL, Dunbar AJ, Mishra T, Xiao W, Waarts MR, Maestre IF, Eisman SE, Cai L, Mowla S, Shah N, Youn A, Bennett L, Fontenard S, Gounder S, Gandhi A, Bowman M, O'Connor K, Zaroogian Z, Sánchez-Vela P, Martinez Benitez AR, Werewski M, Park Y, Csete IS, Krishnan A, Lee D, Boorady N, Potts CR, Jenkins MT, Cai SF, Carroll MP, Meyer SE, Miles LA, Ferrell PB Jr, Trowbridge JJ, Levine RL. Bowman RL, et al. Among authors: zaroogian z. Cancer Cell. 2024 Nov 11;42(11):1955-1969.e7. doi: 10.1016/j.ccell.2024.10.009. Cancer Cell. 2024. PMID: 39532065
Jak2V617F Reversible Activation Shows Its Essential Requirement in Myeloproliferative Neoplasms.
Dunbar AJ, Bowman RL, Park YC, O'Connor K, Izzo F, Myers RM, Karzai A, Zaroogian Z, Kim WJ, Fernández-Maestre I, Waarts MR, Nazir A, Xiao W, Codilupi T, Brodsky M, Farina M, Cai L, Cai SF, Wang B, An W, Yang JL, Mowla S, Eisman SE, Hanasoge Somasundara AV, Glass JL, Mishra T, Houston R, Guzzardi E, Martinez Benitez AR, Viny AD, Koche RP, Meyer SC, Landau DA, Levine RL. Dunbar AJ, et al. Among authors: zaroogian z. Cancer Discov. 2024 May 1;14(5):737-751. doi: 10.1158/2159-8290.CD-22-0952. Cancer Discov. 2024. PMID: 38230747 Free PMC article.
Hematopoietic-specific heterozygous loss of Dnmt3a exacerbates colitis-associated colon cancer.
Feng Y, Yuan Q, Newsome RC, Robinson T, Bowman RL, Zuniga AN, Hall KN, Bernsten CM, Shabashvili DE, Krajcik KI, Gunaratne C, Zaroogian ZJ, Venugopal K, Casellas Roman HL, Levine RL, Chatila WK, Yaeger R, Riva A, Jobin C, Kopinke D, Avram D, Guryanova OA. Feng Y, et al. Among authors: zaroogian zj. J Exp Med. 2023 Nov 6;220(11):e20230011. doi: 10.1084/jem.20230011. Epub 2023 Aug 24. J Exp Med. 2023. PMID: 37615936 Free PMC article.
CXCL8/CXCR2 signaling mediates bone marrow fibrosis and is a therapeutic target in myelofibrosis.
Dunbar AJ, Kim D, Lu M, Farina M, Bowman RL, Yang JL, Park Y, Karzai A, Xiao W, Zaroogian Z, O'Connor K, Mowla S, Gobbo F, Verachi P, Martelli F, Sarli G, Xia L, Elmansy N, Kleppe M, Chen Z, Xiao Y, McGovern E, Snyder J, Krishnan A, Hill C, Cordner K, Zouak A, Salama ME, Yohai J, Tucker E, Chen J, Zhou J, McConnell T, Migliaccio AR, Koche R, Rampal R, Fan R, Levine RL, Hoffman R. Dunbar AJ, et al. Among authors: zaroogian z. Blood. 2023 May 18;141(20):2508-2519. doi: 10.1182/blood.2022015418. Blood. 2023. PMID: 36800567 Free PMC article.
DNMT3A Harboring Leukemia-Associated Mutations Directs Sensitivity to DNA Damage at Replication Forks.
Venugopal K, Feng Y, Nowialis P, Xu H, Shabashvili DE, Berntsen CM, Kaur P, Krajcik KI, Taragjini C, Zaroogian Z, Casellas Román HL, Posada LM, Gunaratne C, Li J, Dupéré-Richer D, Bennett RL, Pondugula S, Riva A, Cogle CR, Opavsky R, Law BK, Bhaduri-McIntosh S, Kubicek S, Staber PB, Licht JD, Bird JE, Guryanova OA. Venugopal K, et al. Among authors: zaroogian z. Clin Cancer Res. 2022 Feb 15;28(4):756-769. doi: 10.1158/1078-0432.CCR-21-2863. Clin Cancer Res. 2022. PMID: 34716195 Free PMC article.