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Page 1
Tambjamines as Fast-Acting Multistage Antimalarials.
Kumar A, Li Y, Dodean RA, Roth A, Caridha D, Madejczyk MS, Jin X, Dennis WE, Lee PJ, Pybus BS, Martin M, Pannone K, Dinh HT, Blount C, Chetree R, DeLuca J, Evans M, Nadeau R, Vuong C, Leed S, Black C, Sousa J, Nolan C, Ceja FG, Rasmussen SA, Tumwebaze PK, Rosenthal PJ, Cooper RA, Rottmann M, Orjuela-Sanchez P, Meister S, Winzeler EA, Delves MJ, Matthews H, Baum J, Kirby RW, Burrows JN, Duffy J, Peyton DH, Reynolds KA, Kelly JX, Kancharla P. Kumar A, et al. Among authors: dodean ra. ACS Infect Dis. 2024 Nov 11. doi: 10.1021/acsinfecdis.4c00659. Online ahead of print. ACS Infect Dis. 2024. PMID: 39526703
Optimization of B-Ring-Functionalized Antimalarial Tambjamines and Prodiginines.
Kumar A, Chithanna S, Li Y, Zhang X, Dodean RA, Caridha D, Madejczyk MS, Lee PJ, Jin X, Chetree R, Blount C, Dennis WE, DeLuca J, Vuong C, Pannone K, Dinh HT, Leed S, Roth A, Reynolds KA, Kelly JX, Kancharla P. Kumar A, et al. Among authors: dodean ra. J Med Chem. 2024 Nov 14;67(21):19755-19776. doi: 10.1021/acs.jmedchem.4c02093. Epub 2024 Oct 19. J Med Chem. 2024. PMID: 39425665 Free PMC article.
3-Position Biaryl Endochin-like Quinolones with Enhanced Antimalarial Performance.
Pou S, Winter RW, Dodean RA, Liebman K, Li Y, Mather MW, Nepal B, Nilsen A, Handford MJ, Riscoe TM, Laxson S, Kirtley PJ, Aleshnick M, Zakharov LN, Kelly JX, Smilkstein MJ, Wilder BK, Kortagere S, Vaidya AB, Alday PH, Doggett JS, Riscoe MK. Pou S, et al. Among authors: dodean ra. ACS Infect Dis. 2024 Jul 12;10(7):2419-2442. doi: 10.1021/acsinfecdis.4c00140. Epub 2024 Jun 11. ACS Infect Dis. 2024. PMID: 38862127
Long-acting intramuscular injections of ELQ-331, an antimalarial agent.
Karunakaran D, Mutyam SK, Fu M, Chen J, Pham KHN, Pou S, Winter RW, Nilsen A, Dodean RA, Smilkstein MJ, Riscoe MK, Shankar G. Karunakaran D, et al. Among authors: dodean ra. Eur J Pharm Sci. 2024 Jul 1;198:106795. doi: 10.1016/j.ejps.2024.106795. Epub 2024 May 8. Eur J Pharm Sci. 2024. PMID: 38729224 Free article.
Discovery and Optimization of Tambjamines as a Novel Class of Antileishmanial Agents.
Kancharla P, Ortiz D, Fargo CM, Zhang X, Li Y, Sanchez M, Kumar A, Yeluguri M, Dodean RA, Caridha D, Madejczyk MS, Martin M, Jin X, Blount C, Chetree R, Pannone K, Dinh HT, DeLuca J, Evans M, Nadeau R, Vuong C, Leed S, Dennis WE, Roncal N, Pybus BS, Lee PJ, Roth A, Reynolds KA, Kelly JX, Landfear SM. Kancharla P, et al. Among authors: dodean ra. J Med Chem. 2024 May 23;67(10):8323-8345. doi: 10.1021/acs.jmedchem.4c00517. Epub 2024 May 9. J Med Chem. 2024. PMID: 38722757 Free PMC article.
Synthesis of Deuterated Endochin-Like Quinolones.
Pou S, Winter RW, Liebman KM, Dodean RA, Nilsen A, DeBarber A, Doggett JS, Riscoe MK. Pou S, et al. Among authors: dodean ra. J Labelled Comp Radiopharm. 2024 May 15;67(5):186-196. doi: 10.1002/jlcr.4092. Epub 2024 Apr 25. J Labelled Comp Radiopharm. 2024. PMID: 38661253
A New Scalable Synthesis of ELQ-300, ELQ-316, and other Antiparasitic Quinolones.
Pou S, Dodean RA, Frueh L, Liebman KM, Gallagher RT, Jin H, Jacobs RT, Nilsen A, Stuart DR, Doggett JS, Riscoe MK, Winter RW. Pou S, et al. Among authors: dodean ra. Org Process Res Dev. 2021 Aug 20;25(8):1841-1852. doi: 10.1021/acs.oprd.1c00099. Epub 2021 Aug 4. Org Process Res Dev. 2021. PMID: 35110959 Free PMC article.
Acridones Are Highly Potent Inhibitors of Toxoplasma gondii Tachyzoites.
Alday PH, McConnell EV, Boitz Zarella JM, Dodean RA, Kancharla P, Kelly JX, Doggett JS. Alday PH, et al. Among authors: dodean ra. ACS Infect Dis. 2021 Jul 9;7(7):1877-1884. doi: 10.1021/acsinfecdis.1c00016. Epub 2021 Mar 16. ACS Infect Dis. 2021. PMID: 33723998 Free PMC article.
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