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The polymeric fluoropyrimidine CF10 overcomes limitations of 5-FU in pancreatic ductal adenocarcinoma cells through increased replication stress.
Finan JM, Di Niro R, Park SY, Jeong KJ, Hedberg MD, Smith A, McCarthy GA, Haber AO, Muschler J, Sears RC, Mills GB, Gmeiner WH, Brody JR. Finan JM, et al. Among authors: haber ao. Cancer Biol Ther. 2024 Dec 31;25(1):2421584. doi: 10.1080/15384047.2024.2421584. Epub 2024 Nov 8. Cancer Biol Ther. 2024. PMID: 39513592 Free PMC article.
Improved Antitumor Activity of the Fluoropyrimidine Polymer CF10 in Preclinical Colorectal Cancer Models through Distinct Mechanistic and Pharmacologic Properties.
Gmeiner WH, Dominijanni A, Haber AO, Ghiraldeli LP, Caudell DL, D'Agostino R Jr, Pasche BC, Smith TL, Deng Z, Kiren S, Mani C, Palle K, Brody JR. Gmeiner WH, et al. Among authors: haber ao. Mol Cancer Ther. 2021 Mar;20(3):553-563. doi: 10.1158/1535-7163.MCT-20-0516. Epub 2020 Dec 23. Mol Cancer Ther. 2021. PMID: 33361273 Free PMC article.
RB Loss Promotes Prostate Cancer Metastasis.
Thangavel C, Boopathi E, Liu Y, Haber A, Ertel A, Bhardwaj A, Addya S, Williams N, Ciment SJ, Cotzia P, Dean JL, Snook A, McNair C, Price M, Hernandez JR, Zhao SG, Birbe R, McCarthy JB, Turley EA, Pienta KJ, Feng FY, Dicker AP, Knudsen KE, Den RB. Thangavel C, et al. Cancer Res. 2017 Feb 15;77(4):982-995. doi: 10.1158/0008-5472.CAN-16-1589. Epub 2016 Dec 6. Cancer Res. 2017. PMID: 27923835 Free PMC article.
Therapeutic Challenge with a CDK 4/6 Inhibitor Induces an RB-Dependent SMAC-Mediated Apoptotic Response in Non-Small Cell Lung Cancer.
Thangavel C, Boopathi E, Liu Y, McNair C, Haber A, Perepelyuk M, Bhardwaj A, Addya S, Ertel A, Shoyele S, Birbe R, Salvino JM, Dicker AP, Knudsen KE, Den RB. Thangavel C, et al. Clin Cancer Res. 2018 Mar 15;24(6):1402-1414. doi: 10.1158/1078-0432.CCR-17-2074. Epub 2018 Jan 8. Clin Cancer Res. 2018. PMID: 29311118 Free PMC article.