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SLC6A19 inhibition facilitates urinary neutral amino acid excretion and lowers plasma phenylalanine.
Wobst HJ, Viader A, Muncipinto G, Hollibaugh R, van Kalken D, Burkhart CT, Cantin SM, Bates RM, Regimbald-Dumas Y, Gross L, Antalek MT, Zweig JE, Wu F, Rettenmaier TJ, Labenski MT, Pullen N, Blanchette HS, Henderson JL, Weng HH, Vaughn TA, Brown DG, Throup JP, Barrish JC. Wobst HJ, et al. Among authors: brown dg. JCI Insight. 2024 Nov 8;9(21):e182876. doi: 10.1172/jci.insight.182876. JCI Insight. 2024. PMID: 39513367 Free article. Clinical Trial.
Novel Corrector for Variants of SLC6A8: A Therapeutic Opportunity for Creatine Transporter Deficiency.
Gechijian LN, Muncipinto G, Rettenmaier TJ, Labenski MT, Rusu V, Rosskamp L, Conway L, van Kalken D, Gross L, Iantosca G, Crotty W, Mathis R, Park H, Rabin B, Westgate C, Lyons M, Deshusses C, Brandon N, Brown DG, Blanchette HS, Pullen N, Jones LH, Barrish JC. Gechijian LN, et al. Among authors: brown dg. ACS Chem Biol. 2024 Nov 15;19(11):2372-2382. doi: 10.1021/acschembio.4c00571. Epub 2024 Oct 17. ACS Chem Biol. 2024. PMID: 39418577 Free PMC article.
The Role of Water Networks in Phosphodiesterase Inhibitor Dissociation and Kinetic Selectivity.
Blaazer AR, Singh AK, Zara L, Boronat P, Bautista LJ, Irving S, Majewski M, Barril X, Wijtmans M, Danielson UH, Sterk GJ, Leurs R, van Muijlwijk-Koezen JE, Brown DG, de Esch IJP. Blaazer AR, et al. Among authors: brown dg. ChemMedChem. 2024 Nov 18;19(22):e202400417. doi: 10.1002/cmdc.202400417. Epub 2024 Sep 12. ChemMedChem. 2024. PMID: 39193819
Sex and Gender Differences in Co-Occurring Alcohol Use Disorder and PTSD.
Saraiya TC, Back SE, Jarnecke AM, Blakey SM, Bauer AG, Brown DG, Ruglass LM, Killeen T, Hien DA. Saraiya TC, et al. Among authors: brown dg. Curr Addict Rep. 2023 Dec;10(4):617-627. doi: 10.1007/s40429-023-00511-5. Epub 2023 Sep 22. Curr Addict Rep. 2023. PMID: 39026610 Free PMC article.
397 results