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Page 1
Discovery of NP3-253, a Potent Brain Penetrant Inhibitor of the NLRP3 Inflammasome.
Mackay A, Velcicky J, Gommermann N, Mattes H, Janser P, Wright M, Dubois C, Brenneisen S, Ilic S, Vangrevelinghe E, Stiefl N, Boettcher A, Schoenboerner M, Vogelsanger M, Muller-Bentz S, Kamke M, Rubert J, Kauffmann M, Desrayaud S, Trunzer M, Srinivas H, Hinniger A, von Burg N, Beltz K, Dekker C, Farady CJ. Mackay A, et al. J Med Chem. 2024 Nov 22. doi: 10.1021/acs.jmedchem.4c02350. Online ahead of print. J Med Chem. 2024. PMID: 39574318
Diffuse pediatric high-grade glioma of methylation-based RTK2A and RTK2B subclasses present distinct radiological and histomolecular features including Gliomatosis cerebri phenotype.
Tauziède-Espariat A, Friker LL, Nussbaumer G, Bison B, Dangouloff-Ros V, Métais A, Sumerauer D, Zamecnik J, Benesch M, Perwein T, van Vuurden D, Wesseling P, La Madrid AM, Garrè ML, Antonelli M, Giangaspero F, Pietsch T, Sturm D, Jones DTW, Pfister SM, Grabovska Y, Mackay A, Jones C, Grill J, Ajlil Y, von Bueren AO, Karremann M, Hoffmann M, Kramm CM, Kwiecien R, Castel D, Gielen GH, Varlet P. Tauziède-Espariat A, et al. Among authors: mackay a. Acta Neuropathol Commun. 2024 Nov 18;12(1):176. doi: 10.1186/s40478-024-01881-1. Acta Neuropathol Commun. 2024. PMID: 39558399 Free PMC article.
GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant.
Liu I, Alencastro Veiga Cruzeiro G, Bjerke L, Rogers RF, Grabovska Y, Beck A, Mackay A, Barron T, Hack OA, Quezada MA, Molinari V, Shaw ML, Perez-Somarriba M, Temelso S, Raynaud F, Ruddle R, Panditharatna E, Englinger B, Mire HM, Jiang L, Nascimento A, LaBelle J, Haase R, Rozowsky J, Neyazi S, Baumgartner AC, Castellani S, Hoffman SE, Cameron A, Morrow M, Nguyen QD, Pericoli G, Madlener S, Mayr L, Dorfer C, Geyeregger R, Rota C, Ricken G, Ligon KL, Alexandrescu S, Cartaxo RT, Lau B, Uphadhyaya S, Koschmann C, Braun E, Danan-Gotthold M, Hu L, Siletti K, Sundström E, Hodge R, Lein E, Agnihotri S, Eisenstat DD, Stapleton S, King A, Bleil C, Mastronuzzi A, Cole KA, Waanders AJ, Montero Carcaboso A, Schüller U, Hargrave D, Vinci M, Carceller F, Haberler C, Slavc I, Linnarsson S, Gojo J, Monje M, Jones C, Filbin MG. Liu I, et al. Among authors: mackay a. Cancer Cell. 2024 Aug 27:S1535-6108(24)00305-2. doi: 10.1016/j.ccell.2024.08.006. Online ahead of print. Cancer Cell. 2024. PMID: 39232581 Free article.
988 results