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Introduction of a carboxylic acid group into pyrazolylpyridine derivatives increased selectivity for inhibition of the 20-HETE synthase CYP4A11/4F2.
Kawamura M, Kobashi Y, Tanaka H, Bohno-Mikami A, Hamada M, Ito Y, Suzuki K, Funayama K, Hirata T, Ohara H, Koretsune H, Kojima N, Fukunaga T, Hirate M, Inatani S, Hasegawa Y, Takahashi T, Kakinuma H. Kawamura M, et al. Among authors: hirate m. Bioorg Med Chem. 2023 Oct 18;95:117505. doi: 10.1016/j.bmc.2023.117505. Online ahead of print. Bioorg Med Chem. 2023. PMID: 39491277
15 results