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A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state.
Knight KM, Krumm BE, Kapolka NJ, Ludlam WG, Cui M, Mani S, Prytkova I, Obarow EG, Lefevre TJ, Wei W, Ma N, Huang XP, Fay JF, Vaidehi N, Smrcka AV, Slesinger PA, Logothetis DE, Martemyanov KA, Roth BL, Dohlman HG. Knight KM, et al. Among authors: roth bl. Nat Commun. 2024 Aug 5;15(1):6643. doi: 10.1038/s41467-024-50964-z. Nat Commun. 2024. PMID: 39103320 Free PMC article.
A proximity proteomics pipeline with improved reproducibility and throughput.
Zhong X, Li Q, Polacco BJ, Patil T, Marley A, Foussard H, Khare P, Vartak R, Xu J, DiBerto JF, Roth BL, Eckhardt M, von Zastrow M, Krogan NJ, Hüttenhain R. Zhong X, et al. Among authors: roth bl. Mol Syst Biol. 2024 Aug;20(8):952-971. doi: 10.1038/s44320-024-00049-2. Epub 2024 Jul 1. Mol Syst Biol. 2024. PMID: 38951684 Free PMC article.
Molecular glues as potential GPCR therapeutics.
Roth BL, Krumm BE. Roth BL, et al. Biochem Pharmacol. 2024 Oct;228:116402. doi: 10.1016/j.bcp.2024.116402. Epub 2024 Jun 28. Biochem Pharmacol. 2024. PMID: 38945274 Review.
AlphaFold2 structures guide prospective ligand discovery.
Lyu J, Kapolka N, Gumpper R, Alon A, Wang L, Jain MK, Barros-Álvarez X, Sakamoto K, Kim Y, DiBerto J, Kim K, Glenn IS, Tummino TA, Huang S, Irwin JJ, Tarkhanova OO, Moroz Y, Skiniotis G, Kruse AC, Shoichet BK, Roth BL. Lyu J, et al. Among authors: roth bl. Science. 2024 Jun 21;384(6702):eadn6354. doi: 10.1126/science.adn6354. Epub 2024 Jun 21. Science. 2024. PMID: 38753765
Piecing together aminergic polypharmacology.
Fordyce BA, Roth BL. Fordyce BA, et al. Among authors: roth bl. Cell Res. 2024 Sep;34(9):599-600. doi: 10.1038/s41422-024-00970-z. Cell Res. 2024. PMID: 38740981 No abstract available.
543 results