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67 results

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Page 1
Dark Microglia Are Abundant in Normal Postnatal Development, where they Remodel Synapses via Phagocytosis and Trogocytosis, and Are Dependent on TREM2.
Vecchiarelli HA, Bisht K, Sharma K, Weiser Novak S, Traetta ME, Garcia-Segura ME, St-Pierre MK, Savage JC, Willis C, Picard K, Bordeleau M, Vernoux N, Khakpour M, Garg R, Loewen SM, Murray CJ, Grinberg YY, Faustino J, Halvorson T, Lau V, Pluchino S, Vexler ZS, Carson MJ, Manor U, Peruzzotti-Jametti L, Tremblay MÈ. Vecchiarelli HA, et al. Among authors: peruzzotti jametti l. bioRxiv [Preprint]. 2024 Oct 18:2024.10.15.618087. doi: 10.1101/2024.10.15.618087. bioRxiv. 2024. PMID: 39463930 Free PMC article. Preprint.
Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis.
Ionescu RB, Nicaise AM, Reisz JA, Williams EC, Prasad P, Willis CM, Simões-Abade MBC, Sbarro L, Dzieciatkowska M, Stephenson D, Suarez Cubero M, Rizzi S, Pirvan L, Peruzzotti-Jametti L, Fossati V, Edenhofer F, Leonardi T, Frezza C, Mohorianu I, D'Alessandro A, Pluchino S. Ionescu RB, et al. Among authors: peruzzotti jametti l. Cell Stem Cell. 2024 Nov 7;31(11):1574-1590.e11. doi: 10.1016/j.stem.2024.09.014. Epub 2024 Oct 21. Cell Stem Cell. 2024. PMID: 39437792 Free article.
Metabolic Control of Microglia.
Garcia-Segura ME, Pluchino S, Peruzzotti-Jametti L. Garcia-Segura ME, et al. Among authors: peruzzotti jametti l. Adv Neurobiol. 2024;37:607-622. doi: 10.1007/978-3-031-55529-9_34. Adv Neurobiol. 2024. PMID: 39207716 Review.
Integrated multi-omics analysis reveals molecular changes associated with chronic lipid accumulation following contusive spinal cord injury.
Yao XQ, Chen JY, Garcia-Segura ME, Wen ZH, Yu ZH, Huang ZC, Hamel R, Liu JH, Shen X, Huang ZP, Lu YM, Zhou ZT, Liu CT, Shi JM, Zhu QA, Peruzzotti-Jametti L, Chen JT. Yao XQ, et al. Among authors: peruzzotti jametti l. Exp Neurol. 2024 Oct;380:114909. doi: 10.1016/j.expneurol.2024.114909. Epub 2024 Aug 5. Exp Neurol. 2024. PMID: 39097074 Free article.
Combination Immunotherapy with Vaccine and Oncolytic HSV Virotherapy Is Time Dependent.
Totsch SK, Ishizuka AS, Kang KD, Gary SE, Rocco A, Fan AE, Zhou L, Valdes PA, Lee S, Li J, Peruzzotti-Jametti L, Blitz S, Garliss CM, Johnston JM, Markert JM, Lynn GM, Bernstock JD, Friedman GK. Totsch SK, et al. Among authors: peruzzotti jametti l. Mol Cancer Ther. 2024 Sep 4;23(9):1273-1281. doi: 10.1158/1535-7163.MCT-23-0873. Mol Cancer Ther. 2024. PMID: 38710101
Mitochondrial complex I activity in microglia sustains neuroinflammation.
Peruzzotti-Jametti L, Willis CM, Krzak G, Hamel R, Pirvan L, Ionescu RB, Reisz JA, Prag HA, Garcia-Segura ME, Wu V, Xiang Y, Barlas B, Casey AM, van den Bosch AMR, Nicaise AM, Roth L, Bates GR, Huang H, Prasad P, Vincent AE, Frezza C, Viscomi C, Balmus G, Takats Z, Marioni JC, D'Alessandro A, Murphy MP, Mohorianu I, Pluchino S. Peruzzotti-Jametti L, et al. Nature. 2024 Apr;628(8006):195-203. doi: 10.1038/s41586-024-07167-9. Epub 2024 Mar 13. Nature. 2024. PMID: 38480879 Free PMC article.
Mitochondrial reverse electron transport in myeloid cells perpetuates neuroinflammation.
Peruzzotti-Jametti L, Willis CM, Hamel R, Krzak G, Reisz JA, Prag HA, Wu V, Xiang Y, van den Bosch AMR, Nicaise AM, Roth L, Bates GR, Huang H, Vincent AE, Frezza C, Viscomi C, Marioni JC, D'Alessandro A, Takats Z, Murphy MP, Pluchino S. Peruzzotti-Jametti L, et al. bioRxiv [Preprint]. 2024 Jan 4:2024.01.03.574059. doi: 10.1101/2024.01.03.574059. bioRxiv. 2024. PMID: 38260262 Free PMC article. Preprint.
Phase I clinical trial of intracerebroventricular transplantation of allogeneic neural stem cells in people with progressive multiple sclerosis.
Leone MA, Gelati M, Profico DC, Gobbi C, Pravatà E, Copetti M, Conti C, Abate L, Amoruso L, Apollo F, Balzano RF, Bicchi I, Carella M, Ciampini A, Colosimo C, Crociani P, D'Aloisio G, Di Viesti P, Ferrari D, Fogli D, Fontana A, Frondizi D, Grespi V, Kuhle J, Laborante A, Lombardi I, Muzi G, Paci F, Placentino G, Popolizio T, Ricciolini C, Sabatini S, Silveri G, Spera C, Stephenson D, Stipa G, Tinella E, Zarrelli M, Zecca C, Ventura Y, D'Alessandro A, Peruzzotti-Jametti L, Pluchino S, Vescovi AL. Leone MA, et al. Among authors: peruzzotti jametti l. Cell Stem Cell. 2023 Dec 7;30(12):1597-1609.e8. doi: 10.1016/j.stem.2023.11.001. Epub 2023 Nov 27. Cell Stem Cell. 2023. PMID: 38016468 Free article. Clinical Trial.
67 results