Michelet R - Search Results

1

Understanding Voriconazole Metabolism: A Middle-Out Physiologically-Based Pharmacokinetic Modelling Framework Integrating In Vitro and Clinical Insights.

Saleh A, Schulz J, Schlender JF, Aulin LBS, Konrad AP, Kluwe F, Mikus G, Huisinga W, Kloft C, Michelet R. Saleh A, et al. Among authors: michelet r. Clin Pharmacokinet. 2024 Oct 30. doi: 10.1007/s40262-024-01434-8. Online ahead of print. Clin Pharmacokinet. 2024. PMID: 39476315

2

Modeling and Simulations in Latin-American Generic Markets: Perspectives from Chilean Local Industry, Regulatory Agency, and Academia.

García MA, Paulos C, Ibarra Viñales M, Michelet R, Cabrera-Pérez MÁ, Aceituno A, Bone M, Ibacache M, Cortínez LI, Guzmán M. García MA, et al. Among authors: michelet r. Mol Pharm. 2024 Oct 25. doi: 10.1021/acs.molpharmaceut.4c00764. Online ahead of print. Mol Pharm. 2024. PMID: 39454202 Review.

3

Exploring the Impact of Developmental Clearance Saturation on Propylene Glycol Exposure in Adults and Term Neonates Using Physiologically Based Pharmacokinetic Modeling.

Olafuyi O, Michelet R, Garle M, Allegaert K. Olafuyi O, et al. Among authors: michelet r. J Clin Pharmacol. 2024 Oct 15. doi: 10.1002/jcph.6150. Online ahead of print. J Clin Pharmacol. 2024. PMID: 39404076

4

A quantitative modeling framework to understand the physiology of the hypothalamic-pituitary-adrenal axis and interaction with cortisol replacement therapy.

Bindellini D, Michelet R, Aulin LBS, Melin J, Neumann U, Blankenstein O, Huisinga W, Whitaker MJ, Ross R, Kloft C. Bindellini D, et al. Among authors: michelet r. J Pharmacokinet Pharmacodyn. 2024 Jul 8. doi: 10.1007/s10928-024-09934-7. Online ahead of print. J Pharmacokinet Pharmacodyn. 2024. PMID: 38977635

5

Population pharmacokinetics of TLD-1, a novel liposomal doxorubicin, in a phase I trial.

Mc Laughlin AM, Hess D, Michelet R, Colombo I, Haefliger S, Bastian S, Rabaglio M, Schwitter M, Fischer S, Eckhardt K, Hayoz S, Kopp C, Klose M, Sessa C, Stathis A, Halbherr S, Huisinga W, Joerger M, Kloft C. Mc Laughlin AM, et al. Among authors: michelet r. Cancer Chemother Pharmacol. 2024 Sep;94(3):349-360. doi: 10.1007/s00280-024-04679-z. Epub 2024 Jun 15. Cancer Chemother Pharmacol. 2024. PMID: 38878207 Free PMC article. Clinical Trial.

6

Personalized Dosing of Medicines for Children: A Primer on Pediatric Pharmacometrics for Clinicians.

Meesters K, Balbas-Martinez V, Allegaert K, Downes KJ, Michelet R. Meesters K, et al. Among authors: michelet r. Paediatr Drugs. 2024 Jul;26(4):365-379. doi: 10.1007/s40272-024-00633-x. Epub 2024 May 16. Paediatr Drugs. 2024. PMID: 38755515 Review.

7

Nonlinear Mixed-Effects Model of Z-Endoxifen Concentrations in Tamoxifen-Treated Patients from the CEPAM Cohort.

Mc Laughlin AM, Helland T, Klima F, Koolen SLW, van Schaik RHN, Mathijssen RHJ, Neven P, Swen JJ, Guchelaar HJ, Dalenc F, White-Koning M, Michelet R, Mikus G, Schroth W, Mürdter T, Brauch H, Schwab M, Søiland H, Mellgren G, Thomas F, Kloft C, Hertz DL; CYP2D6 Endoxifen Percentage Activity Model (CEPAM) Consortium. Mc Laughlin AM, et al. Among authors: michelet r. Clin Pharmacol Ther. 2024 Sep;116(3):690-702. doi: 10.1002/cpt.3238. Epub 2024 Mar 18. Clin Pharmacol Ther. 2024. PMID: 38494911

8

Bayesian framework for multi-source data integration-Application to human extrapolation from preclinical studies.

Boulet S, Ursino M, Michelet R, Aulin LB, Kloft C, Comets E, Zohar S. Boulet S, et al. Among authors: michelet r. Stat Methods Med Res. 2024 Apr;33(4):574-588. doi: 10.1177/09622802241231493. Epub 2024 Mar 6. Stat Methods Med Res. 2024. PMID: 38446999

9

C-Reactive Protein as an Early Predictor of Efficacy in Advanced Non-Small-Cell Lung Cancer Patients: A Tumor Dynamics-Biomarker Modeling Framework.

Nassar YM, Ojara FW, Pérez-Pitarch A, Geiger K, Huisinga W, Hartung N, Michelet R, Holdenrieder S, Joerger M, Kloft C. Nassar YM, et al. Among authors: michelet r. Cancers (Basel). 2023 Nov 15;15(22):5429. doi: 10.3390/cancers15225429. Cancers (Basel). 2023. PMID: 38001689 Free PMC article.

10

Towards Model-Informed Precision Dosing of Voriconazole: Challenging Published Voriconazole Nonlinear Mixed-Effects Models with Real-World Clinical Data.

Kluwe F, Michelet R, Huisinga W, Zeitlinger M, Mikus G, Kloft C. Kluwe F, et al. Among authors: michelet r. Clin Pharmacokinet. 2023 Oct;62(10):1461-1477. doi: 10.1007/s40262-023-01274-y. Epub 2023 Aug 21. Clin Pharmacokinet. 2023. PMID: 37603216 Free PMC article.

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