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Knockdown of Ketohexokinase Versus Inhibition of Its Kinase Activity Exert Divergent Effects on Fructose Metabolism.
Park SH, Fadhul T, Conroy LR, Clarke HA, Sun RC, Wallenius K, Boucher J, O'Mahony G, Boianelli A, Persson M, Jung S, Jang C, Loria AS, Martinez GJ, Kipp ZA, Bates EA, Hinds TD Jr, Divanovic S, Softic S. Park SH, et al. Among authors: divanovic s. JCI Insight. 2024 Oct 17:e184396. doi: 10.1172/jci.insight.184396. Online ahead of print. JCI Insight. 2024. PMID: 39418102 Free article.
IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice.
Harley IT, Stankiewicz TE, Giles DA, Softic S, Flick LM, Cappelletti M, Sheridan R, Xanthakos SA, Steinbrecher KA, Sartor RB, Kohli R, Karp CL, Divanovic S. Harley IT, et al. Among authors: divanovic s. Hepatology. 2014 May;59(5):1830-9. doi: 10.1002/hep.26746. Epub 2014 Mar 27. Hepatology. 2014. PMID: 24115079 Free PMC article.
Fructose and hepatic insulin resistance.
Softic S, Stanhope KL, Boucher J, Divanovic S, Lanaspa MA, Johnson RJ, Kahn CR. Softic S, et al. Among authors: divanovic s. Crit Rev Clin Lab Sci. 2020 Aug;57(5):308-322. doi: 10.1080/10408363.2019.1711360. Epub 2020 Jan 14. Crit Rev Clin Lab Sci. 2020. PMID: 31935149 Free PMC article. Review.
Fructose Induced KHK-C Increases ER Stress and Modulates Hepatic Transcriptome to Drive Liver Disease in Diet-Induced and Genetic Models of NAFLD.
Park SH, Helsley RN, Fadhul T, Willoughby JLS, Noetzli L, Tu HC, Solheim MH, Fujisaka S, Pan H, Dreyfuss JM, Bons J, Rose J, King CD, Schilling B, Lusis AJ, Pan C, Gupta M, Kulkarni RN, Fitzgerald K, Kern PA, Divanovic S, Kahn CR, Softic S. Park SH, et al. Among authors: divanovic s. bioRxiv [Preprint]. 2023 Jan 27:2023.01.27.525605. doi: 10.1101/2023.01.27.525605. bioRxiv. 2023. Update in: Metabolism. 2023 Aug;145:155591. doi: 10.1016/j.metabol.2023.155591. PMID: 36747758 Free PMC article. Updated. Preprint.
Fructose induced KHK-C can increase ER stress independent of its effect on lipogenesis to drive liver disease in diet-induced and genetic models of NAFLD.
Park SH, Helsley RN, Fadhul T, Willoughby JLS, Noetzli L, Tu HC, Solheim MH, Fujisaka S, Pan H, Dreyfuss JM, Bons J, Rose J, King CD, Schilling B, Lusis AJ, Pan C, Gupta M, Kulkarni RN, Fitzgerald K, Kern PA, Divanovic S, Kahn CR, Softic S. Park SH, et al. Among authors: divanovic s. Metabolism. 2023 Aug;145:155591. doi: 10.1016/j.metabol.2023.155591. Epub 2023 May 23. Metabolism. 2023. PMID: 37230214 Free PMC article.
Peroxisomal β-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease.
Moreno-Fernandez ME, Giles DA, Stankiewicz TE, Sheridan R, Karns R, Cappelletti M, Lampe K, Mukherjee R, Sina C, Sallese A, Bridges JP, Hogan SP, Aronow BJ, Hoebe K, Divanovic S. Moreno-Fernandez ME, et al. Among authors: divanovic s. JCI Insight. 2018 Mar 22;3(6):e93626. doi: 10.1172/jci.insight.93626. JCI Insight. 2018. PMID: 29563328 Free PMC article.
Type I interferons regulate susceptibility to inflammation-induced preterm birth.
Cappelletti M, Presicce P, Lawson MJ, Chaturvedi V, Stankiewicz TE, Vanoni S, Harley IT, McAlees JW, Giles DA, Moreno-Fernandez ME, Rueda CM, Senthamaraikannan P, Sun X, Karns R, Hoebe K, Janssen EM, Karp CL, Hildeman DA, Hogan SP, Kallapur SG, Chougnet CA, Way SS, Divanovic S. Cappelletti M, et al. Among authors: divanovic s. JCI Insight. 2017 Mar 9;2(5):e91288. doi: 10.1172/jci.insight.91288. JCI Insight. 2017. PMID: 28289719 Free PMC article.
88 results