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Page 1
Sensitivity and specificity of a seed amplification assay for diagnosis of multiple system atrophy: a multicentre cohort study.
Ma Y, Farris CM, Weber S, Schade S, Nguyen H, Pérez-Soriano A, Giraldo DM, Fernández M, Soto M, Cámara A, Painous C, Muñoz E, Valldeoriola F, Martí MJ, Clarimon J, Kallunki P, Ma TC, Alcalay RN, Gomes BF, Blennow K, Zetterberg H, Constantinescu J, Mengel D, Kadam V, Parchi P, Brockmann K, Tropea TF, Siderowf A, Synofzik M, Kang UJ, Compta Y, Svenningsson P, Mollenhauer B, Concha-Marambio L. Ma Y, et al. Among authors: concha marambio l. Lancet Neurol. 2024 Dec;23(12):1225-1237. doi: 10.1016/S1474-4422(24)00395-8. Lancet Neurol. 2024. PMID: 39577923
Association of CSF α-synuclein seed amplification assay positivity with disease progression and cognitive decline: A longitudinal Alzheimer's Disease Neuroimaging Initiative study.
Tosun D, Hausle Z, Thropp P, Concha-Marambio L, Lamoureux J, Lebovitz R, Shaw LM, Singleton AB, Weiner MW; Alzheimer's Disease Neuroimaging Initiative; Blauwendraat C. Tosun D, et al. Among authors: concha marambio l. Alzheimers Dement. 2024 Oct 20. doi: 10.1002/alz.14276. Online ahead of print. Alzheimers Dement. 2024. PMID: 39428831
Misfolded alpha synuclein co-occurrence with Alzheimer's disease proteinopathy.
Jonaitis EM, MacLeod K, Lamoureux J, Jeffers B, Studer RL, Middleton J, Wilson RE, Chin NA, Okonkwo OC, Bendlin BB, Asthana S, Carlsson CM, Gallagher CL, Hermann B, McEvoy S, Kollmorgen G, Zetterberg H, Concha-Marambio L, Johnson SC, Lebovitz RM, Langhough RE. Jonaitis EM, et al. Among authors: concha marambio l. medRxiv [Preprint]. 2024 Oct 13:2024.10.11.24315349. doi: 10.1101/2024.10.11.24315349. medRxiv. 2024. PMID: 39417113 Free PMC article. Preprint.
Neuronal alpha-Synuclein Disease integrated staging system performance in PPMI, PASADENA, and SPARK baseline cohorts.
Dam T, Pagano G, Brumm MC, Gochanour C, Poston KL, Weintraub D, Chahine LM, Coffey C, Tanner CM, Kopil CM, Xiao Y, Chowdhury S, Concha-Marambio L, DiBiaso P, Foroud T, Frasier M, Jennings D, Kieburtz K, Merchant K, Mollenhauer B, Montine TJ, Nudelman K, Seibyl J, Sherer T, Singleton A, Stephenson D, Stern M, Soto C, Tolosa E, Siderowf A, Dunn B, Simuni T, Marek K; Parkinson’s Progression Markers Initiative. Dam T, et al. Among authors: concha marambio l. NPJ Parkinsons Dis. 2024 Sep 27;10(1):178. doi: 10.1038/s41531-024-00789-w. NPJ Parkinsons Dis. 2024. PMID: 39333167 Free PMC article.
Neuronal alpha-Synuclein Disease Integrated Staging System performance in PPMI, PASADENA, and SPARK baseline cohorts.
Dam T, Pagano G, Brumm MC, Gochanour C, Poston KL, Weintraub D, Chahine LM, Coffey C, Tanner CM, Kopil CM, Xiao Y, Chowdhury S, Concha-Marambio L, DiBiaso P, Foroud T, Frasier M, Jennings D, Kieburtz K, Merchant K, Mollenhauer B, Montine TJ, Nudelman K, Seibyl J, Sherer T, Singleton A, Stephenson D, Stern M, Soto C, Tolosa E, Siderowf A, Dunn B, Simuni T, Marek K; Parkinson’s Progression Markers Initiative. Dam T, et al. Among authors: concha marambio l. medRxiv [Preprint]. 2024 Sep 10:2024.02.14.24302818. doi: 10.1101/2024.02.14.24302818. medRxiv. 2024. Update in: NPJ Parkinsons Dis. 2024 Sep 27;10(1):178. doi: 10.1038/s41531-024-00789-w PMID: 39314957 Free PMC article. Updated. Preprint.
Association of CSF α-Synuclein Seed Amplification Assay Positivity with Disease Progression and Cognitive Decline: A Longitudinal Alzheimer's Disease Neuroimaging Initiative Study.
Tosun D, Hausle Z, Thropp P, Concha-Marambio L, Lamoureux J, Lebovitz R, Shaw LM, Singleton AB, Weiner MW; Alzheimer’s Disease Neuroimaging Initiative; Blauwendraat C. Tosun D, et al. Among authors: concha marambio l. medRxiv [Preprint]. 2024 Jul 16:2024.07.16.24310496. doi: 10.1101/2024.07.16.24310496. medRxiv. 2024. Update in: Alzheimers Dement. 2024 Oct 20. doi: 10.1002/alz.14276 PMID: 39072013 Free PMC article. Updated. Preprint.
Target engagement and immunogenicity of an active immunotherapeutic targeting pathological α-synuclein: a phase 1 placebo-controlled trial.
Eijsvogel P, Misra P, Concha-Marambio L, Boyd JD, Ding S, Fedor L, Hsieh YT, Sun YS, Vroom MM, Farris CM, Ma Y, de Kam ML, Radanovic I, Vissers MFJM, Mirski D, Shareghi G, Shahnawaz M, Singer W, Kremer P, Groeneveld GJ, Yu HJ, Dodart JC. Eijsvogel P, et al. Among authors: concha marambio l. Nat Med. 2024 Sep;30(9):2631-2640. doi: 10.1038/s41591-024-03101-8. Epub 2024 Jun 20. Nat Med. 2024. PMID: 38902546 Free PMC article. Clinical Trial.
Clinicopathological correlation of cerebrospinal fluid alpha-synuclein seed amplification assay in a behavioral neurology autopsy cohort.
Samudra N, Fischer DL, Lenio S, Lario Lago A, Ljubenkov PA, Rojas JC, Seeley WW, Spina S, Staffaroni AM, Tablante J, Wekselman F, Lamoureux J, Concha-Marambio L, Grinberg LT, Boxer AL, VandeVrede L. Samudra N, et al. Among authors: concha marambio l. Alzheimers Dement. 2024 May;20(5):3334-3341. doi: 10.1002/alz.13799. Epub 2024 Mar 27. Alzheimers Dement. 2024. PMID: 38539061 Free PMC article.
Investigating alpha-synuclein co-pathology in Alzheimer's disease by means of cerebrospinal fluid alpha-synuclein seed amplification assay.
Bellomo G, Toja A, Paolini Paoletti F, Ma Y, Farris CM, Gaetani L, Salvadori N, Chiasserini D, Wojdaƚa AL, Concha-Marambio L, Parnetti L. Bellomo G, et al. Among authors: concha marambio l. Alzheimers Dement. 2024 Apr;20(4):2444-2452. doi: 10.1002/alz.13658. Epub 2024 Feb 7. Alzheimers Dement. 2024. PMID: 38323747 Free PMC article.
A biological definition of neuronal α-synuclein disease: towards an integrated staging system for research.
Simuni T, Chahine LM, Poston K, Brumm M, Buracchio T, Campbell M, Chowdhury S, Coffey C, Concha-Marambio L, Dam T, DiBiaso P, Foroud T, Frasier M, Gochanour C, Jennings D, Kieburtz K, Kopil CM, Merchant K, Mollenhauer B, Montine T, Nudelman K, Pagano G, Seibyl J, Sherer T, Singleton A, Stephenson D, Stern M, Soto C, Tanner CM, Tolosa E, Weintraub D, Xiao Y, Siderowf A, Dunn B, Marek K. Simuni T, et al. Among authors: concha marambio l. Lancet Neurol. 2024 Feb;23(2):178-190. doi: 10.1016/S1474-4422(23)00405-2. Lancet Neurol. 2024. PMID: 38267190 Review.
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